Blocklisting Interim Review

Phytopharm PLC
23 September 2005


                    BLOCKLISTING SIX MONTHLY REVIEW


1. NAME OF COMPANY:

   PHYTOPHARM PLC


2. NAME OF SCHEME:

   THE PHYTOPHARM 1996 UNAPPROVED DISCRETIONARY SHARE OPTION


3. PERIOD OF RETURN:     FROM:            TO:

                         17TH MARCH 2005  16TH SEPTEMBER 2005


4. NUMBER AND CLASS OF SHARE(S)
   (AMOUNT OF STOCK/DEBT SECURITY)
   NOT ISSUED UNDER SCHEME
   AT END OF THE LAST PERIOD:

   140,712 ORDINARY SHAES OF 1 PENCE


5. NUMBER OF SHARES ISSUED/ALLOTTED
   UNDER SCHEME DURING PERIOD:

   NIL


6. BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED 
   AT END OF PERIOD:

   140,712 ORDINARY SHARES OF 1 PENCE


7. NUMBER AND CLASS OF SHARE(S) 
   (AMOUNT OF STOCK/DEBT SECURITIES) 
   ORIGINALLY LISTED AND THE DATE OF ADMISSION:

   400,000 ORDINARY SHARES OF 1 PENCE ON 16TH MARCH 2004

PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD
IN ORDER FOR US TO UPDATE OUR RECORDS.

   TOTAL SHARES IN ISSUE 51,180,893 ORDINARY SHARES OF 1 PENCE AT 16TH SEPTEMBER
   2005

CONTACT FOR QUERIES

NAME:                              DR G W CHONG

TELEPHONE:                         01480 437697


                      This information is provided by RNS
            The company news service from the London Stock Exchange