Blocklisting Interim Review

Phytopharm PLC
01 November 2006

                      BLOCKLISTING SIX MONTHLY RETURN

INFORMATION PROVIDED ON THIS FORM MUST BE TYPED OR PRINTED ELECTRONICALLY.


To:  The FSA

Date:  1 NOVEMBER 2006      


1. Name of applicant:              PHYTOPHARM PLC



2. Name of scheme                  THE PHYTOPHARM 1996 UNAPPROVED 
                                   DISCRETIONARY SHARE OPTION SCHEME



3. Period of return:               From  1 MAY 2006     To   30 OCTOBER 2006


4. Balance under scheme from previous return:     

159,660 ORDINARY SHARES OF 1 PENCE



5. The amount by which the block scheme has been increased, if the scheme has 
been increased since the date of the last return:

NIL

6. Number of securities issued/allotted under scheme during period:

NIL

7. Balance under scheme not yet issued / allotted at end of period

159,660 ORDINARY SHARES OF 1 PENCE

8. Number and class of securities originally listed and the date of admission

400,000 ORDINARY SHARES OF 1 PENCE

9. Total number of securities in issue at the end of the period

51,180,893 ORDINARY SHARES OF 1 PENCE


Name of contact                     ZOE McGOWAN


Address of contact                  CORPUS CHRISTI HOUSE, 9 WEST STREET,
                                    GODMANCHESTER


Telephone number of contact         01480 437697


Signed by

Company secretary
for and on behalf of



PHYTOPHARM PLC



If you knowingly or recklessly give false or misleading information you may be
liable to prosecution.




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