Director Shareholding

Phytopharm PLC 1 December 2000 DEALINGS BY DIRECTORS 1) NAME OF COMPANY PHYTOPHARM PLC 2) NAME OF DIRECTOR Dr RICHARD DIXEY 3) Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 or in respect of an non-beneficial interest AS 2 4) Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them. (If notified) AS 2 5) Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s) 6) Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary 7) Number of shares/amount of stock acquired 8) (N/A %) of issued Class 9) Number of shares/amount of stock disposed 10) ( N/A %) of issued Class 11) Class of security 12) Price per share 13) Date of transaction 14) Date company informed 15) Total holding following this notification 16) Total percentage holding of issued class following this notification IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE COMPLETE THE FOLLOWING BOXES 17) Date of grant 30 NOVEMBER 2000 18) Period during which or date on which exercisable 17,110 - 1 DEC 2003 TO 30 NOV 2007 17,110 - 1 DEC 2005 - 30 NOV 2007 19) Total amount paid (if any) for grant of the option NIL 20) Description of shares or debentures involved: class, number. 34,220 ORDINARY 1 pence 21) Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise £6.575 22) Total number of shares or debentures over which options held following this notification 483,963 23) Any additional information 24) Name of contact and telephone number for queries S LOACH - 01480-437697 25) Name and signature of authorised company official responsible for making this notification Date of Notification 1 DECEMBER 2000 DEALINGS BY DIRECTORS 1) NAME OF COMPANY PHYTOPHARM PLC 2) NAME OF DIRECTOR Ms JAYNE ALLAN 3) Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 or in respect of an non-beneficial interest AS 2 4) Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them. (If notified) AS 2 5) Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s) 6) Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary 7) Number of shares/amount of stock acquired 8) (N/A %) of issued Class 9) Number of shares/amount of stock disposed 10) ( N/A %) of issued Class 11) Class of security 12) Price per share 13) Date of transaction 14) Date company informed 15) Total holding following this notification 16) Total percentage holding of issued class following this notification IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE COMPLETE THE FOLLOWING BOXES 17) Date of grant 30 NOVEMBER 2000 18) Period during which or date on which exercisable 4,038 - 1 DEC 2003 TO 30 NOV 2007 7,984 - 1 DEC 2005 - 30 NOV 2007 19) Total amount paid (if any) for grant of the option NIL 20) Description of shares or debentures involved: class, number. 12,022 ORDINARY 1 pence 21) Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise £6.575 22) Total number of shares or debentures over which options held following this notification 208,000 23) Any additional information 24) Name of contact and telephone number for queries S LOACH - 01480-437697 25) Name and signature of authorised company official responsible for making this notification Date of Notification 1 DECEMBER 2000 DEALINGS BY DIRECTORS 1) NAME OF COMPANY PHYTOPHARM PLC 2) NAME OF DIRECTOR Dr SIMON LOACH 3) Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 or in respect of an non-beneficial interest AS 2 4) Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them. (If notified) AS 2 5) Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s) 6) Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary 7) Number of shares/amount of stock acquired 8) (N/A %) of issued Class 9) Number of shares/amount of stock disposed 10) ( N/A %) of issued Class 11) Class of security 12) Price per share 13) Date of transaction 14) Date company informed 15) Total holding following this notification 16) Total percentage holding of issued class following this notification IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE COMPLETE THE FOLLOWING BOXES 17) Date of grant 30 NOVEMBER 2000 18) Period during which or date on which exercisable 3,036 - 1 DEC 2003 TO 30 NOV 2007 3,036 - 1 DEC 2005 - 30 NOV 2007 19) Total amount paid (if any) for grant of the option NIL 20) Description of shares or debentures involved: class, number. 6,072 ORDINARY 1 pence 21) Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise £6.575 22) Total number of shares or debentures over which options held following this notification 435,276 23) Any additional information 24) Name of contact and telephone number for queries S LOACH - 01480-437697 25) Name and signature of authorised company official responsible for making this notification Date of Notification 1 DECEMBER 2000 DEALINGS BY DIRECTORS 1) NAME OF COMPANY PHYTOPHARM PLC 2) NAME OF DIRECTOR Dr DARYL REES 3) Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 or in respect of an non-beneficial interest AS 2 4) Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them. (If notified) AS 2 5) Please state whether notification relates to a person(s) connected with the Director named in 2 above and identify the connected person(s) 6) Please state the nature of the transaction. For PEP transactions please indicate whether general/single co PEP and if discretionary/non discretionary 7) Number of shares/amount of stock acquired 8) (N/A %) of issued Class 9) Number of shares/amount of stock disposed 10) ( N/A %) of issued Class 11) Class of security 12) Price per share 13) Date of transaction 14) Date company informed 15) Total holding following this notification 16) Total percentage holding of issued class following this notification IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE COMPLETE THE FOLLOWING BOXES 17) Date of grant 30 NOVEMBER 2000 18) Period during which or date on which exercisable 11,407 - 1 DEC 2003 TO 30 NOV 2007 11,406 - 1 DEC 2005 - 30 NOV 2007 19) Total amount paid (if any) for grant of the option NIL 20) Description of shares or debentures involved: class, number. 22,813 ORDINARY 1 pence 21) Exercise price (if fixed at time of grant) or indication that price is to be fixed at time of exercise £6.575 22) Total number of shares or debentures over which options held following this notification 142,813 23) Any additional information 24) Name of contact and telephone number for queries S LOACH - 01480-437697 25) Name and signature of authorised company official responsible for making this notification Date of Notification 1 DECEMBER 2000

Companies

Ixico (IXI)
UK 100