Director Shareholding

Phytopharm PLC
7 December 2001


                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    PHYTOPHARM PLC

2)  NAME OF DIRECTOR

    MS J.E. ALLAN

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    AS 2

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    AS 2

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary



7)  Number of shares/amount of
    stock acquired



8)   (N/A %)
    of issued Class



9)  Number of shares/amount
    of stock disposed



10)  ( N/A %)
    of issued Class



11) Class of security



12) Price per share



13) Date of transaction



14) Date company informed



15) Total holding following this notification



16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant

    6 DECEMBER 2001

18) Period during which or date on which exercisable

    5497 7 DEC 2004 - 5 DEC 2008
    5497 7 DEC 2006 - 5 DEC 2008

19) Total amount paid (if any) for grant of the option

    NIL

20) Description of shares or debentures involved: class, number.

    10,994 ORDINARY 1 PENCE

21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise

    £4.775

22) Total number of shares or debentures over which options held
    following this notification

    218994

23) Any additional information



24) Name of contact and telephone number for queries

    S. LOACH      01480 437697

25) Name and signature of authorised company official responsible for
    making this notification

    Date of Notification      7 DECEMBER 2001                             



                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    PHYTOPHARM PLC

2)  NAME OF DIRECTOR

    DR R.P. DIXEY

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    AS 2

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    AS 2

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)



6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary



7)  Number of shares/amount of
    stock acquired



8)   (N/A %)
    of issued Class



9)  Number of shares/amount
    of stock disposed



10)  ( N/A %)
    of issued Class



11) Class of security



12) Price per share



13) Date of transaction



14) Date company informed



15) Total holding following this notification



16) Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant

    6 DECEMBER 2001

18) Period during which or date on which exercisable

    19,633 7 DEC 2004 - 5 DEC 2008
    19,634 7 DEC 2006 - 5 DEC 2008

19) Total amount paid (if any) for grant of the option

    NIL

20) Description of shares or debentures involved: class, number.

    39,267 ORDINARY 1 PENCE

21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise

    £4.775

22) Total number of shares or debentures over which options held
    following this notification

    523,230

23) Any additional information



24) Name of contact and telephone number for queries

    S. LOACH      01480 437697

25) Name and signature of authorised company official responsible for
    making this notification

    Date of Notification      7 DECEMBER 2001                             



                       DEALINGS BY DIRECTORS


1)  NAME OF COMPANY

    PHYTOPHARM PLC

2)  NAME OF DIRECTOR

    DR S.C. LOACH

3)  Please state whether notification indicates that it is in respect of
    holding of the shareholder named in 2 above or in respect of a
    non-beneficial interest or in the case of an individual holder
    if it is a holding of that person's spouse or children under the
    age of 18 or in respect of an non-beneficial interest

    AS 2

4)  Name of the registered holder(s) and, if more than one holder, the
    number of shares held by each of them. (If notified)

    AS 2

5)  Please state whether notification relates to a person(s) connected
    with the Director named in 2 above and identify the connected person(s)

    DIRECTOR ONLY

6)  Please state the nature of the transaction. For PEP transactions
    please indicate whether general/single co PEP and if discretionary/non
    discretionary

    EXERCISE OF OPTION AND MARKET SALE

7)  Number of shares/amount of
    stock acquired

    300,000

8)   (0.78%)
     of issued Class



9)  Number of shares/amount
    of stock disposed

    300,000

10)  (0.78%)
     of issued Class



11) Class of security

    ORDINARY

12) Price per share

    BOUGHT       75,000 AT £0.2625
                149,721 AT £1.925
                 75,279 AT £0.45

    SOLD £5.35

13) Date of transaction

    7 DEC 2001

14) Date company informed

    7 DEC 2001

15) Total holding following this notification

    0.01%

16) Total percentage holding of issued class following this notification

    0.01%

     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17) Date of grant

    6 DECEMBER 2001

18) Period during which or date on which exercisable

    8,361 7 DEC 2004 - 5 DEC 2008
    8,361 7 DEC 2006 - 5 DEC 2008

19) Total amount paid (if any) for grant of the option

    NIL

20) Description of shares or debentures involved: class, number.

    16,722 ORDINARY 1 PENCE

21) Exercise price (if fixed at time of grant) or indication that price
    is to be fixed at time of exercise

    £4.775

22) Total number of shares or debentures over which options held
    following this notification

    134,443

23) Any additional information



24) Name of contact and telephone number for queries

    S. LOACH      01480 437697

25) Name and signature of authorised company official responsible for
    making this notification

    Date of Notification      7 DECEMBER 2001