Director Shareholding

Phytopharm PLC
6 January 2004



                                  SCHEDULE 11

          NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS


1)   NAME OF COMPANY

     PHYTOPHARM PLC


2)   NAME OF DIRECTOR

     DR R P DIXEY


3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder
     if it is a holding of that person's spouse or children under the
     age of 18 or in respect of an non-beneficial interest

     AS 2 ABOVE


4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them. (If notified)

     AS 2 ABOVE


5)   Please state whether notification relates to a person(s) connected
     with the Director named in 2 above and identify the connected person(s)

     AS 2 ABOVE


6)   Please state the nature of the transaction. For PEP transactions
     please indicate whether general/single co PEP and if discretionary/non
     discretionary

     GRANT OF SHARE OPTIONS UNDER THE PHYTOPHARM SHARE OPTION PLAN 2003


7)   Number of shares/amount of stock acquired



8)   Percentage of issued Class



9)   Number of shares/amount
     of stock disposed



10)  Percentage of issued Class
     (any treasury shares held by company should not be taken into account when
     calculating percentage)



11)  Class of security



12)  Price per share



13)  Date of transaction



14)  Date company informed



15)  Total holding following this notification



16)  Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17)  Date of grant

     9 DECEMBER 2003


18)  Period during which or date on which exercisable

     10 DECEMBER 2006 TO 9 DECEMBER 2013 SUBJECT TO PERFORMANCE CRITERIA


19)  Total amount paid (if any) for grant of the option

     NIL


20)  Description of shares or debentures involved: class, number.

     51,249 PHYTOPHARM PLC ORDINARY 1 PENCE SHARES


21)  Exercise price (if fixed at time of grant) or indication that price
     is to be fixed at time of exercise

     212.5 PENCE


22)  Total number of shares or debentures over which options held
     following this notification

     595,509


23)  Any additional information

     PERFORMANCE CRITERIA ARE BASED ON TOTAL SHAREHOLDER RETURN COMPARED TO 
     COMPARATOR GROUPS AT THE THIRD, FOURTH AND FIFTH ANNIVERSARIES OF GRANT. NO
     OPTIONS VEST FOR BELOW MEDIAN PERFORMANCE, 25% VEST FOR MEDIAN PERFORMANCE
     AND 100% VEST FOR UPPER DECILE AND ABOVE WITH PRORATE VESTING BETWEEN 
     MEDIAN AND UPPER DECILE PERFORMANCE. FOR 34,168 OPTIONS THE COMPARATOR 
     GROUP COMPRISES 19 OTHER UK LISTED BIOTECH COMPANIES, AND FOR 17,081 
     OPTIONS THE COMPARATOR GROUP IS THE FTSE SMALL CAP INDEX


24)  Name of contact and telephone number for queries

     DR G W CHONG
     1480 437697


25)  Name and signature of authorised company official responsible for
     making this notification

     Date of Notification    6 JANUARY 2004                           



                                  SCHEDULE 11

          NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS


1)   NAME OF COMPANY

     PHYTOPHARM PLC


2)   NAME OF DIRECTOR

     DR D D REES


3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder
     if it is a holding of that person's spouse or children under the
     age of 18 or in respect of an non-beneficial interest

     AS 2 ABOVE


4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them. (If notified)

     AS 2 ABOVE


5)   Please state whether notification relates to a person(s) connected
     with the Director named in 2 above and identify the connected person(s)

     AS 2 ABOVE


6)   Please state the nature of the transaction. For PEP transactions
     please indicate whether general/single co PEP and if discretionary/non
     discretionary

     GRANT OF SHARE OPTIONS UNDER THE PHYTOPHARM SHARE OPTION PLAN 2003


7)   Number of shares/amount of stock acquired



8)   Percentage of issued Class



9)   Number of shares/amount
     of stock disposed



10)  Percentage of issued Class
     (any treasury shares held by company should not be taken into account when
     calculating percentage)



11)  Class of security



12)  Price per share



13)  Date of transaction



14)  Date company informed



15)  Total holding following this notification



16)  Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17)  Date of grant

     9 DECEMBER 2003


18)  Period during which or date on which exercisable

     10 DECEMBER 2006 TO 9 DECEMBER 2013 SUBJECT TO PERFORMANCE CRITERIA


19)  Total amount paid (if any) for grant of the option

     NIL


20)  Description of shares or debentures involved: class, number.

     62,304 PHYTOPHARM PLC ORDINARY 1 PENCE SHARES


21)  Exercise price (if fixed at time of grant) or indication that price
     is to be fixed at time of exercise

     212.5 PENCE


22)  Total number of shares or debentures over which options held
     following this notification

     621,318


23)  Any additional information

     PERFORMANCE CRITERIA ARE BASED ON TOTAL SHAREHOLDER RETURN COMPARED TO 
     COMPARATOR GROUPS AT THE THIRD, FOURTH AND FIFTH ANNIVERSARIES OF GRANT. NO
     OPTIONS VEST FOR BELOW MEDIAN PERFORMANCE, 25% VEST FOR MEDIAN PERFORMANCE
     AND 100% VEST FOR UPPER DECILE AND ABOVE WITH PRORATE VESTING BETWEEN 
     MEDIAN AND UPPER DECILE PERFORMANCE. FOR 41,538 OPTIONS THE COMPARATOR 
     GROUP COMPRISES 19 OTHER UK LISTED BIOTECH COMPANIES, AND FOR 20,766 
     OPTIONS THE COMPARATOR GROUP IS THE FTSE SMALL CAP INDEX


24)  Name of contact and telephone number for queries

     DR G W CHONG
     1480 437697


25)  Name and signature of authorised company official responsible for
     making this notification

     Date of Notification    6 JANUARY 2004                           


                                  SCHEDULE 11

          NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED PERSONS


1)   NAME OF COMPANY

     PHYTOPHARM PLC


2)   NAME OF DIRECTOR

     DR G W CHONG


3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder
     if it is a holding of that person's spouse or children under the
     age of 18 or in respect of an non-beneficial interest

     AS 2 ABOVE


4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them. (If notified)

     AS 2 ABOVE


5)   Please state whether notification relates to a person(s) connected
     with the Director named in 2 above and identify the connected person(s)

     AS 2 ABOVE


6)   Please state the nature of the transaction. For PEP transactions
     please indicate whether general/single co PEP and if discretionary/non
     discretionary

     GRANT OF SHARE OPTIONS UNDER THE PHYTOPHARM SHARE OPTION PLAN 2003


7)   Number of shares/amount of stock acquired



8)   Percentage of issued Class



9)   Number of shares/amount
     of stock disposed



10)  Percentage of issued Class
     (any treasury shares held by company should not be taken into account when
     calculating percentage)



11)  Class of security



12)  Price per share



13)  Date of transaction



14)  Date company informed



15)  Total holding following this notification



16)  Total percentage holding of issued class following this notification



     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17)  Date of grant

     9 DECEMBER 2003


18)  Period during which or date on which exercisable

     10 DECEMBER 2006 TO 9 DECEMBER 2013 SUBJECT TO PERFORMANCE CRITERIA


19)  Total amount paid (if any) for grant of the option

     NIL


20)  Description of shares or debentures involved: class, number.

     35,124 PHYTOPHARM PLC ORDINARY 1 PENCE SHARES


21)  Exercise price (if fixed at time of grant) or indication that price
     is to be fixed at time of exercise

     212.5 PENCE


22)  Total number of shares or debentures over which options held
     following this notification

     145,932


23)  Any additional information

     PERFORMANCE CRITERIA ARE BASED ON TOTAL SHAREHOLDER RETURN COMPARED TO 
     COMPARATOR GROUPS AT THE THIRD, FOURTH AND FIFTH ANNIVERSARIES OF GRANT. NO
     OPTIONS VEST FOR BELOW MEDIAN PERFORMANCE, 25% VEST FOR MEDIAN PERFORMANCE
     AND 100% VEST FOR UPPER DECILE AND ABOVE WITH PRORATE VESTING BETWEEN 
     MEDIAN AND UPPER DECILE PERFORMANCE. FOR 23,418 OPTIONS THE COMPARATOR 
     GROUP COMPRISES 19 OTHER UK LISTED BIOTECH COMPANIES, AND FOR 11,706 
     OPTIONS THE COMPARATOR GROUP IS THE FTSE SMALL CAP INDEX


24)  Name of contact and telephone number for queries

     DR G W CHONG
     1480 437697


25)  Name and signature of authorised company official responsible for
     making this notification

     Date of Notification    6 JANUARY 2004                           


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