Director Shareholding

Phytopharm PLC
3 December 2004

                                   SCHEDULE 11

                  NOTIFICATION OF INTERESTS OF DIRECTORS AND CONNECTED 
                                       PERSONS


1)   NAME OF COMPANY

PHYTOPHARM PLC

2)   NAME OF DIRECTOR

DR R P DIXEY

3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder
     if it is a holding of that person's spouse or children under the
     age of 18 or in respect of an non-beneficial interest

AS IN 2 ABOVE

4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them. (If notified)

AS IN 2 ABOVE

5)   Please state whether notification relates to a person(s) connected
     with the Director named in 2 above and identify the connected person(s)

AS IN 2 ABOVE

6)   Please state the nature of the transaction. For PEP transactions
     please indicate whether general/single co PEP and if discretionary/non
     discretionary

EXERCISE OF SHARE OPTIONS UNDER THE 1996 COMPANY SHARE OPTION SCHEME

7)   Number of shares/amount of
     stock acquired

288,889

8)   Percentage of issued Class
(ANY TREASURY SHARES HELD BY COMPANY SHOULD NOT BE TAKEN INTO ACCOUNT
WHEN CALCULATING PERCENTAGE)

0.0068%

9)   Number of shares/amount
     of stock disposed

NONE

10)  Percentage of issued Class
(ANY TREASURY SHARES HELD BY COMPANY SHOULD NOT BE TAKEN INTO ACCOUNT
WHEN CALCULATING PERCENTAGE)



11)  Class of security

ORDINARY

12)  Price per share

EXERCISE PRICE 45 PENCE

13)  Date of transaction

3 DECEMBER 2004

14)  Date company informed

3 DECEMBER 2004

15)  Total holding following this notification

543,964

16)  Total percentage holding of issued class following this notification
(ANY TREASURY SHARES HELD BY COMPANY SHOULD NOT BE TAKEN INTO ACCOUNT
WHEN CALCULATING PERCENTAGE)

0.013%

     IF A DIRECTOR HAS BEEN GRANTED OPTIONS BY THE COMPANY PLEASE
                    COMPLETE THE FOLLOWING BOXES

17)  Date of grant



18)  Period during which or date on which exercisable



19)  Total amount paid (if any) for grant of the option



20)  Description of shares or debentures involved: class, number.



21)  Exercise price (if fixed at time of grant) or indication that price
     is to be fixed at time of exercise



22)  Total number of shares or debentures over which options held
     following this notification



23)  Any additional information



24)  Name of contact and telephone number for queries

DR WANG CHONG
01480 437697


25)  Name and signature of authorised company official responsible for
     making this notification

     Date of Notification   3 DECEMBER 2004                              



END



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