Holding(s) in Company

Phytopharm PLC
14 October 2002


Phytopharm PLC ( the 'Company')

Notification of Major Interests in Shares

The Company received a notification on 11 October 2002 from AMVESCAP PLC,
informing it that following a purchase of 775,000 shares on 10 October 2002 ,
AMVESCAP PLC and subsidiary companies on behalf of discretionary clients have a
non beneficial interest in 5,110,228 ordinary 1p shares, representing 13.24% of
the issued ordinary share capital of the Company.

The Shares are registered in the following names:

Vidacos Nominees Limited                                        3,926,054
HSBC Nominees Limited                                             675,430
Chase Nominees Limited                                            192,000
Bank of New York Nominees Ltd                                     173,172
Northern Trust Nominees Limited                                    85,000
Mellon Bank Pittsburgh Nominees                                    58,572



14 October, 2002


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