Holding(s) in Company

Phytopharm PLC
15 October 2002


Phytopharm PLC ( the 'Company')

Notification of Major Interests in Shares


The Company received a notification today from AMVESCAP PLC, informing it that
following a purchase of 500,000 shares on 14 October 2002 , AMVESCAP PLC and
subsidiary companies on behalf of discretionary clients have a non beneficial
interest in 5,610,228 ordinary 1p shares, representing 14.53% of the issued
ordinary share capital of the Company.

The Shares are registered in the following names:

Vidacos Nominees Limited                            4,402,834

HSBC Nominees Limited                               692,016

Chase Nominees Limited                              192,000

Bank of New York Nominees Ltd                       179,806

Northern Trust Nominees Limited                     85,000

Mellon Bank Pittsburgh Nominees                     58,572


In addition the Company received a notification today from AMVESCAP PLC,
informing it that, INVESCO Perpetual Income Fund has an interest in 2,117,072
ordinary 1p shares, representing 5.48% of the issued ordinary share capital of
the Company. The shares are registered in the name of Vidacos Nominees Limited.

15 October, 2002


                      This information is provided by RNS
            The company news service from the London Stock Exchange