Holding(s) in Company

Phytopharm PLC
20 April 2004


Re: Notification of Major Interests in Shares

The Company received notification on 19 April 2004 from HBOS plc that HBOS plc
has a material interest (for the purposes of Sections 208 and 209 of the Act) in
1,736,654 Ordinary shares of 1p. This represents 4.06% of the issued share
capital. Details of the interest are set out below:

HDSL Nominees Limited                                          9 
HSBC Global Custody Nominees (UK) Ltd a/c 823733          30,596 
HSBC Global Custody Nominees (UK) Ltd a/c 823721          35,930 
HSBC Global Custody Nominees (UK) Ltd a/c 823587         310,987 
HSBC Global Custody Nominees (UK) Ltd a/c 823575         434,448 
HSBC Global Custody Nominees (UK) Ltd a/c 823496         924,684


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