Holding(s) in Company

Phytopharm PLC
27 November 2007



TR-1: NOTIFICATION OF MAJOR INTERESTS IN SHARES 

1. Identity of the issuer or the underlying                
issuer of existing shares to which voting rightsare attached:

Phytopharm plc

2. Reason for the notification (please tick the appropriate box or
boxes)                                                                    

An acquisition or disposal of voting rights                               ( )                             

An acquisition or disposal of financial instruments which may result
in acquisition of shares already issued to which voting rights are 
attached                                                                  ( )

An event changing the breakdown of voting rights                          (X)                        

Other (please specify):notification obligation:                           ( )                            


3. Full name of person(s) subject to the                    Henderson Global
notification obligation:                                    Investors Limited 

                                                       
4. Full name of shareholder(s) (if different
from 3.):                                               


5. Date of the transaction (and date on which                07/03/2007
the threshold is crossed or reached if                  
different)


6. Date on which issuer notified:                            16/11/2007
                        

7. Threshold(s) that is/are crossed or
reached:                                                       5%
                             
8. Notified details:

A: Voting rights attached to shares

Class/type  Situation previous to the Resulting situation after the triggering
of shares   Triggering transaction    transaction
if possible
using the   Number of    Number of    Number of    Number of voting      % of voting
ISIN CODE   Shares       Voting       shares       rights                rights
                         Rights       Direct       Direct x     Indirect Direct  Indirect
                                                                xi
Ordinary 1
Pence        2,885,032    2,885,032    3,134,490    3,134,490        -    5.64%       -
GB000686972


B: Financial Instruments

Resulting situation after the triggering transaction
Type of     Expiration Exercise/     Number of voting rights that may   % of
financial   date       Conversion    be acquired if the instrument is   voting
instrument             Period/ Date  exercised/ converted.              rights



Total (A+B)

Number of voting rights                      % of voting rights

         3,134,490                                5.64%


9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:



Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:


13. Additional information:        Notification using the total voting rights 
                                   figure of 55,606,309

14. Contact name:                  Zoe McGowan, Company Secretary

15. Contact telephone number:      01480 437697




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