Holding(s) in Company

Phytopharm PLC
28 March 2008



TR-1: Notification of major interests in shares

1. Identity of the issuer or the underlying                Phytopharm plc
issuer of existing shares to which voting rights        
are attached:

2. Reason for the notification (please tick the appropriate box or
boxes)                                                                      

An acquisition or disposal of voting rights                 X
                        
An acquisition or disposal of financial instruments which may result in     
the acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights                            

Other (please specify):

3. Full name of person(s) subject to the                  Deutsche Bank AG
notification obligation:                                

4. Full name of shareholder(s) (if different
from 3.):                                            

5. Date of the transaction (and date on which                26/03/2008
the threshold is crossed or reached if different)

6. Date on which issuer notified:                            27/03/2008
                    
7. Threshold(s) that is/are crossed or reached:              3% and 4%
                    
8. Notified details:
                    
A: Voting rights attached to shares
Class/type  Situation         Resulting situation after the triggering
of shares   previous to the   transaction
if possible Triggering
using the   transaction
ISIN CODE 
            Number Number of  Number of    Number of voting      % of voting
            of     Voting     shares       rights                rights
            Shares Rights     Direct       Direct x  Indirectxi Direct Indirect
                              
Ordinary 1
Pence       N/A    N/A         2,500,000    2,500,000        -    4.5%       -
GB000686972

B: Financial Instruments
Resulting situation after the triggering transaction
Type of     Expiration Exercise/     Number of voting rights that may   % of
financial   date       Conversion    be acquired if the instrument is   voting
instrument             Period/ Date  exercised/ converted.              rights


Total (A+B)
Number of voting rights                      % of voting rights
2,500,500                                     4.5%

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional           Notification using the total voting rights figure of
information:             55,6612,926

14. Contact name:        Zoe McGowan, Company Secretary

15. Contact telephonenumber:01480 437697




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