Holding(s) in Company

Phytopharm PLC
29 November 2004


The Company received notification on 25 November 2004 that following the 
purchase of 100,000 Ordinary 1p shares on 23 November 2004, Amvescap plc and its
subsidiary companies on behalf of discretionary clients have an interest (within 
the meaning of Part VI of Section 198 of the Companies Act 1985) in 4,731,817 
Ordinary 1p shares. This represents 11.06% of the issued share capital. Details 
of the registered holders (as required by Section 202(3) of the Act) are set out 
below:

Vidacos Nominees Ltd                 1,406,108 
HSBC Nominees Ltd                    1,959,879 
Chase Nominees Ltd                     769,619 
Bank of New York Nominees Ltd          392,818 
Northern Trust Nominees Ltd            203,393



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