Holding(s) in Company

Phytopharm PLC 7 March 2005 Re: Disclosure of interests in shares In accordance with Section 198-202 of the UK Companies Act 1985, HBOS plc informed us on 7th March 2005 that it and its subsidiary companies have a notifiable interest in 2,701,463 ordinary shares of Phytopharm plc, amounting to 4.81%, on the basis of Phytopharm's current issued share capital of 43,099,700 ordinary shares. Registered Holder: Fund: Number of Percentage Shares Held: Holding: HSDL Nominees Limited N/A 36 0.00% State Street Nominees Limited a/c 2GEH 2GEH 40,596 0.09% State Street Nominees Limited a/c 2GDX 2GDX 46,839 0.11% State Street Nominees Limited a/c 2GEG 2GEG 340,079 0.79% State Street Nominees Limited a/c 2GDW 2GDW 443,539 1.03% State Street Nominees Limited a/c 2GDS 2GDS 1,200,374 2.79% Aggregate material Holding of HBOS Group 2,071,463 4.81% This information is provided by RNS The company news service from the London Stock Exchange LFBEXBZBBZ

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