Holding(s) in Company

Phytopharm PLC
9 May 2005

Letter to RNS

Dated: 9 May 2005

Re:  Disclosure of interests in shares

In accordance with Section 198-202 of the UK Companies Act 1985, M & G
Investment Management Limited informed us on 5th May 2005, that Prudential plc
and certain of its subsidiary companies have a notifiable interest in 1,551,306
ordinary shares of Phytopharm plc, amounting to 3.03%, on the basis of
Phytopharm's current issued share capital of 51,180,893 ordinary shares.

Registered holder:                       Number of             Percentage
                                         Shares held           Holding 

PRUCLT HSBC GIS NOM(UK) PAC AC           1,512,797             2.956%
PRUCLT GIS NOM(UK)PPL AC                 33,509                0.065%
Prudential Holborn Pensions Limited      5,000                 0.000%

Letter from: Dr G W Chong
             Chief Financial Officer
             Phytopharm


                      This information is provided by RNS
            The company news service from the London Stock Exchange