Holding(s) in Company

Phytopharm PLC
20 April 2005

Re: Disclosure of interests in shares

In accordance with Section 198-202 of the UK Companies Act 1985, FMR Corp, the
parent holding of Fidelity Management & Research Company (FMRCO), and Fidelity
International Limited (FIL) informed us on 20 April 2005 that it and its
subsidiary companies, including Fidelity Investment Services Ltd (FISL) and Mr
Edward C Johnson 3rd of 82 Devonshire Street, Boston MA 02109, a principal
shareholder of FMR Corp and FIL, no longer have a notifiable interest in the
ordinary shares of Phytopharm plc based on an issued share capital of 43,099,700
ordinary shares

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