Holding(s) in Company

Phytopharm PLC
07 March 2007


                                                                    

TR-1: NOTIFICATION OF MAJOR INTERESTS IN SHARES


(1). Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

PHYTOPHARM PLC


2. Reason for the notification (please state Yes/No): (   )

An acquisition or disposal of voting rights:                               ( X )

An acquisition or disposal of financial instruments which may result 
in the acquisition of shares already issued to which voting rights are 
attached:                                                                  (   )

An event changing the breakdown of voting rights:                          (   )

Other (please specify) :                                                   (   )


 
3. Full name of person(s) subject to the notification obligation:

HENDERSON GLOBAL INVESTORS LIMITED
 

4. Full name of shareholder(s) (if different from 3.):


 

5. Date of the transaction and date on which the threshold is crossed or reached
if different):

07/03/2007
 

6. Date on which issuer notified:

07/03/2007
 

7. Threshold(s) that is/are crossed or reached:

6%
 

8. Notified details:


 


A: Voting rights attached to shares

 
Class/type of shares            Situation previous to  
if possible using the           the Triggering         
ISIN CODE                       transaction        
                       Number of shares       Number of voting Rights 


ORDINARY 1 PENCE     2,885,032         2,885,032

GB000686972

 

                     Resulting situation after the triggering transaction 
 
Class/type of shares Number of shares  Number of voting rights    % of voting rights  
if possible using                                                                 
the ISIN CODE                                                                         
                     Direct            Direct     Indirect        Direct    Indirect  


ORDINARY 1 PENCE     3,134,490         3,134,490   -              6.12%      -

GB000686972


B: Financial Instruments

Resulting situation after the triggering transaction 

Type of     Expiration Date  Exercise/Conversion Number of voting     % of voting     
financial                    Period/ Date        rights that may be   rights          
instrument                                       acquired if the                      
                                                 instrument is                        
                                                 exercised/                           
                                                 converted.                           

 

Total (A+B)
Number of voting rights       % of voting rights 

3,134,490                     6.12%
 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:


 


Proxy Voting:

 
10. Name of the proxy holder:


 

11. Number of voting rights proxy holder will cease to hold:


 

12. Date on which proxy holder will cease to hold voting rights:


 

13. Additional information:

NOTIFICATION USING THE TOTAL VOTING RIGHTS FIGURE OF 51,180,893
 

14. Contact name:


ZOE MCGOWAN, COMPANY SECRETARY 

15. Contact telephone number:

01480 437697


 
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