Research Update

Phytopharm PLC 20 March 2002 20 March 2002 Phytopharm plc Commences European multi-centre study of P7v in canine atopic dermatitis Phytopharm plc (PYM: London Stock Exchange) ('Phytopharm') announces today the start of a European multi-centre study of P7v, its novel, patented botanical product for the treatment of canine atopic dermatitis (canine 'eczema'). This randomised, double blind, placebo controlled study will be conducted by specialist veterinary dermatologists located in France and the United Kingdom. The study will determine the optimal dose for future commercialisation of the product, which consists of granules presented in a foil sachet. One hundred and twenty dogs with perennial atopic dermatitis will be randomly allocated to one of four dose groups. The owners will add the appropriate dose of either P7v or the matching placebo product to their dogs' food once daily for 12 weeks. The response to dosing will be assessed by changes in the canine atopic dermatitis extent and severity index (CADESI), severity of pruritus, the incidence of secondary skin infection and the overall response reported by both the veterinarians and dog owners. The study is expected to complete in Q4 2002 and will be reported in Q1 2003. The global market for health and nutrition products used by dogs and cats is estimated to be worth $2.21 billion annually (Vivash-Jones Consultants-1999). There are approximately 95 million dogs in the US, Europe and Japan. As a condition, atopic dermatitis is the largest disease segment believed to affect up to 15% of the entire canine population with 80% of those affected having perennial signs of the condition (Muller & Kirk's Small Animal Dermatology, 6th Edition). Dr Richard Dixey, Chief Executive of Phytopharm, said: 'There is a requirement for new therapies that are effective and well-tolerated for the treatment of canine eczema as there are few presently available. I am encouraged by our good progress with this product which addresses a potentially substantial market.' Enquiries: Phytopharm plc Dr Richard Dixey, Chief Executive Tel: 01480 437697 Mobile: 07867 782000 Financial Dynamics Tel: 0207 831 3113 David Yates Notes To Editors Phytopharm plc Phytopharm is the leading company in the development of Botanical pharmaceuticals. Botanicals enable the rapid clinical evaluation of plant medicines in chronic and poorly understood diseases. Where novel modes of action are discovered, such research can form the basis for drug discovery platforms, which enable the development of new medicines and the isolation of single chemical entities of clinical importance. Phytopharm has four drug discovery platforms in full development, for obesity and metabolic syndrome, neural and muscular degeneration, inflammation and dermatitis. Phytopharm is developing nine products based on its four drug discovery platforms alongside a number of other projects in early evaluation phase. More information concerning Phytopharm's activities can be found on its Web site at http://www.phytopharm.co.uk This information is provided by RNS The company news service from the London Stock Exchange

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