Director/PDMR Shareholding

Oxford Biomedica PLC
05 July 2006


                       Oxford BioMedica plc ('the Company')


                Directors' Interest in Shares and Share Options



Oxford BioMedica (OXB:L) The Company today announced that Peter Nolan and Andrew
Wood, both directors of the Company, have exercised options over 162,162 and
82,197 1p ordinary shares respectively.

The options which have been exercised were granted on 17 August 1999, and if not
exercised, would otherwise lapse on 17 August 2006. Peter Nolan and Andrew Wood
have sold today 148,262 and 75,152 shares respectively at 24.5 pence per share,
this being the amount necessary to fund the exercise of the options and the
associated tax liability. The remaining shares, 13,900 and 7,045 respectively,
have been retained, increasing both directors' holdings of 1p ordinary shares.


The total interests of Peter Nolan and Andrew Wood in the Company's 1p ordinary
shares and share options following these transactions are:

                                                 Shares         Share options
Peter Nolan                                      163,638        558,704
Andrew Wood                                      205,067        616,261


The exercise price for the options exercised today was 21p per share. The newly
allotted shares are subject to a block listing, so are already listed. Including
these shares, the total number of the Company's issued 1p ordinary shares is now
499,950,764.



Andrew Wood
Company Secretary, Oxford BioMedica plc
5 July 2006



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