Director/PDMR Shareholding

Oxford Biomedica PLC
16 March 2006


                      Oxford BioMedica plc ('the Company')

                Directors' Interest in Shares and Share Options

Oxford BioMedica (OXB:L) The Company today announced that Peter Nolan and Andrew
Wood, both directors of the Company, have exercised options over 162,162, and
560,433 and 1p ordinary shares respectively.

The options which have been exercised were granted on 1 April 1999, and if not
exercised, would otherwise lapse on 1 April 2006. Peter Nolan and Andrew Wood
have both sold today all the shares allotted on the exercise of these options at
29 pence per share.

The total interests of Peter Nolan and Andrew Wood in the Company's 1p ordinary
shares and share options following these transactions are:

                                             Shares              Share options
--------------------------                 ---------          ----------------

Peter Nolan                                 149,738                    720,866
Andrew Wood                                 198,022                    698,458

The exercise price for the options exercised today was 21p per share. The newly
allotted shares are subject to a block listing, so are already listed. Including
these shares, the total number of the Company's issued 1p ordinary shares is now
499,576,839.

Andrew Wood
Company Secretary, Oxford BioMedica plc
16 March 2006



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