Director Shareholding

Oxford Biomedica PLC
12 October 2004


                      Oxford BioMedica plc ('the Company')

             Directors' Interest in Options over 1p Ordinary Shares

                                12 October 2004

The Company announced that today it has granted additional share options to
certain Directors, under the Oxford BioMedica 1996 (No.1) Share Option Scheme.
The exercise price for each of the options is 20.5 pence per share. There was no
payment in respect of the grant of these options. The new options may be
exercised between 12 October 2007 and 12 October 2011, but only if at the time
of exercise, or for at least 12 months in the three years before exercise, the
percentage increase in Oxford BioMedica's Total Shareholder Return exceeds the
percentage increase in the FTSE TechMark Mediscience index since the date of
grant of the option. The new options granted to directors are: Professor Alan
Kingsman 190,000 options, Professor Susan Kingsman 155,000 options, Peter Nolan
140,000 options and Andrew Wood 175,000 options.

Following the grant of these options, the interests of these directors in
options over 1p ordinary shares of the Company are: Professor Alan Kingsman
370,000 options, Professor Susan Kingsman 305,000 options, Peter Nolan 1,111,229
options and Andrew Wood 1,505,036 options.

Andrew Wood
Company Secretary, Oxford BioMedica plc
Tel. [phone]
12 October 2004


                      This information is provided by RNS
            The company news service from the London Stock Exchange