Holding(s) in Company

Oxford Biomedica PLC
05 April 2007


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached (ii):

Oxford BioMedica PLC


2. Reason for the notification (please state Yes/No): ( )

An acquisition or disposal of voting rights: ( )

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: ( )

An event changing the breakdown of voting rights: ( )

Other (please specify): (Yes) A purchase of shares has caused a subsidiary of
Prudential plc to cross the 4% threshold


3. Full name of person(s) subject to the notification obligation (iii):

Prudential plc group of companies


4. Full name of shareholder(s) (if different from 3.) (iv):

Prudential plc (parent company)

M&G Group Limited (wholly owned subsidiary of Prudential plc)

M&G Investment Management Limited (wholly owned subsidiary of M&G Limited)

M&G Limited (wholly owned subsidiary of M&G Group Limited)

The Prudential Assurance Company Limited (wholly owned subsidiary of Prudential
plc)



5. Date of the transaction (and date on which the threshold is crossed or
reached if different) (v):

03 April 2007


6. Date on which issuer notified:

05 April 2007


7. Threshold(s) that is/are crossed or reached:

The Prudential Assurance Company Limited (a wholly owned subsidiary of
Prudential plc) has increased above a 4% notifiable interest


8. Notified details:


A: Voting rights attached to shares

Class/type of shares if possible using Situation previous to the Triggering transaction
the ISIN CODE                                                (vi)
                                        Number of shares  Number of voting Rights (viii)
GB0006648157                                  43,402,426                      43,402,426


Resulting situation after the triggering transaction (vii)
Class/type of shares if        Number of shares Number of voting rights (ix)  % of voting rights
possible using the ISIN
CODE
                                         Direct    Direct (x)  Indirect (xi)     Direct   Indirect
GB0006648157                         43,902,426    43,902,426                     8.22%


B: Financial Instruments

Resulting situation after the triggering transaction (xii)
Type of        Expiration Date (    Exercise/Conversion      Number of voting rights   % of voting rights
financial      xiii)                Period/Date (xiv)        that may be acquired if
instrument                                                   the instrument is
                                                             exercised/ converted.

N/A            N/A                  N/A                      N/A                       N/A


Total (A+B)
    Number of voting rights     % of voting rights

    43,902,426                  8.22%


9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable (xv):
                   Registered Holder                                        Holding          %

Prudential plc                                                           43,902,426       8.22
                   Norturst Nominee Ltd A/C MHF01                           134,616
                   Nortrust Nominee Ltd A/C MKK01                        22,200,582
                   Nortrust Noms Ltd                                        170,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                       18,500,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                        2,896,860

M&G Group Limited                                                        43,902,426       8.22
                   Norturst Nominee Ltd A/C MHF01                           134,616
                   Nortrust Nominee Ltd A/C MKK01                        22,200,582
                   Nortrust Noms Ltd                                        170,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                       18,500,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                        2,896,860

M&G Limited                                                              43,902,426       8.22
                   Norturst Nominee Ltd A/C MHF01                           134,616
                   Nortrust Nominee Ltd A/C MKK01                        22,200,582
                   Nortrust Noms Ltd                                        170,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                       18,500,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                          896,860

M&G Investment Management Limited                                        43,767,810       8.20
                   Nortrust Nominee Ltd A/C MKK01                        22,200,582
                   Nortrust Noms Ltd                                        170,000
                   PRUCLT HSBC GIS NOM (UK) PAC AC                       18,500,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                        2,896,860

The Prudential Assurance Company Limited                                 21,397,228       4.01
                   PRUCLT HSBC GIS NOM (UK) PAC AC                       18,500,368
                   PRUCLT HSBC GIS NOM (UK) PPL AC                        2,896,860



Proxy Voting:

10. Name of the proxy holder:

N/A


11. Number of voting rights proxy holder will cease to hold:

N/A



12. Date on which proxy holder will cease to hold voting rights:

N/A


13. Additional information:

None


14. Contact name:

Andrew Wood


15. Contact telephone number:

01865 783000


Annex to Notification Of Major Interests In Shares (xvi)


A: Identity of the person or legal entity subject to the notification obligation


Full name (including legal form for legal entities):

Prudential plc


Contact address (registered office for legal entities):

Laurence Pountney Hill, London EC4R 0HH


Phone number:

020 7626 4588


Other useful information (at least legal representative for legal persons):

N/A


B: Identity of the notifier, if applicable (xvii)


Full name:

Emma Thompson


Contact address:

Prudential plc

Laurence Pountney Hill, London EC4R 0HH


Phone number:

020 7548 2293



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