Holding(s) in Company

Oxford Biomedica PLC
22 February 2007


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached (ii):

Oxford BioMedica PLC


2. Reason for the notification (please state Yes/No): ( )

An acquisition or disposal of voting rights: (Yes)

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: ( )

An event changing the breakdown of voting rights: ( )

Other (please specify) : ( )


3. Full name of person(s) subject to the notification obligation (iii):

Credit Agricole Cheuvreux International Ltd


4. Full name of shareholder(s) (if different from 3.) (iv):

Credit Agricole Cheuvreux International Ltd
Credit Agricole Asset Management Group


5. Date of the transaction (and date on which the threshold is crossed or
reached if different) (v):

19 February 2007


6. Date on which issuer notified:

21 February 2007


7. Threshold(s) that is/are crossed or reached:

8% to 9%


8. Notified details:


A: Voting rights attached to shares

Class/type of shares                Situation previous to the Triggering transaction (vi)   
if possible using the ISIN CODE                                                
                                        Number of shares      Number of voting Rights (viii)
GB0006648157                                  44,981,502                          44,981,502


Resulting situation after the triggering transaction (vii)
Class/type of shares if        Number of shares Number of voting rights (ix)  % of voting rights
possible using the ISIN
CODE
                                         Direct    Direct (x)  Indirect (xi)     Direct   Indirect
GB0006648157                         45,291,422    45,291,422                     9.03%


B: Financial Instruments

Resulting situation after the triggering transaction (xii)
Type of        Expiration Date     Exercise/Conversion      Number of voting rights     % of voting rights
financial      (xiii)                Period/Date (xiv)        that may be acquired if
instrument                                                   the instrument is
                                                             exercised/ converted.

N/A            N/A                      N/A                       N/A                    N/A


Total (A+B)
    Number of voting rights     % of voting rights
                 45,291,422                  9.03%


9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable (xv):
                   Registered Holder                                       Holding          %

                   SAS Rue La Boetie
                   Credit Agricole SA
                   Calyon SA
                   Credit Agricole Cheuvreux SA                         44,568,957      8.89%
                   Credit Agricole Asset Management Group


Proxy Voting:

10. Name of the proxy holder:

N/A


11. Number of voting rights proxy holder will cease to hold:

N/A



12. Date on which proxy holder will cease to hold voting rights:

N/A


13. Additional information:

None


14. Contact name:

Andrew Wood


15. Contact telephone number:

01865 783000


Annex to Notification Of Major Interests In Shares (xvi)


A: Identity of the person or legal entity subject to the notification obligation


Full name (including legal form for legal entities):

Credit Agricole Cheuvreux International Ltd


Contact address (registered office for legal entities):

Broadwalk House, 5 Appold Street, London EC2A 2DA


Phone number:

020 7214 5282


Other useful information (at least legal representative for legal persons):

N/A


B: Identity of the notifier, if applicable (xvii)


Full name:

Karen Browne


Contact address:

Calyon Corporate and Investment Bank

Broadwalk House, 5 Appold Street, London EC2A 2DA


Phone number:

020 7214 5282



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