Holding(s) in Company

Oxford Biomedica PLC
22 May 2007


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Identity of the issuer or the underlying issuer of existing shares to which
   voting rights are attached (ii):

   Oxford BioMedica PLC

2. Reason for the notification (please state Yes/No): ( )

   An acquisition or disposal of voting rights: (Yes)
   An acquisition or disposal of financial instruments which may result in the
   acquisition of shares already issued to which voting rights are attached: ( )
   An event changing the breakdown of voting rights: ( )
   Other (please specify) : ( )

3. Full name of person(s) subject to the notification obligation (iii):

   GAM International Management Limited

4. Full name of shareholder(s) (if different from 3.) (iv):

   n/a

5. Date of the transaction (and date on which the threshold is crossed or
   reached if different) (v):

   17 May 2007

6. Date on which issuer notified:

   21 May 2007

7. Threshold(s) that is/are crossed or reached:

   4% to 5%

8. Notified details:

A: Voting rights attached to shares

Class/type of shares Situation previous to the Triggering transaction
if possible using                          (vi)
the ISIN CODE
                      Number of shares  Number of voting Rights (viii)
GB0006648157                                                24,857,684


Resulting situation after the triggering transaction (vii)
Class/type of shares  Number of shares    Number of voting       % of voting
if possible using                           rights (ix)            rights
the ISIN CODE
                                Direct Direct (x)    Indirect   Direct Indirect
                                                         (xi)
GB0006648157                29,857,684 29,857,684                5.59%


B: Financial Instruments

Resulting situation after the triggering transaction (xii)
Type of     Expiration Date  Exercise/Conversion Number of voting     % of voting
financial   (xiii)           Period/Date (xiv)   rights that may be   rights
instrument                                       acquired if the
                                                 instrument is
                                                 exercised/
                                                 converted.
N/A                    N/A                 N/A                 N/A            N/A


Total (A+B)
 Number of voting rights  % of voting rights
              29,857,684               5.59%


9. Chain of controlled undertakings through which the voting rights and/or the
   financial instruments are effectively held, if applicable (xv):
   GAM International Management Limited is the discretionary investment manager
   for the following funds/holdings:
                                                            Nominal        %
   SJPI GAM Sterling Managed Fund                           983,763   0.184%
   SJPI GAM US Dollar Managed Fund                          151,874   0.028%
   GAM Global Diversified                                 1,410,123   0.264%
   GAM UK Diversified                                    12,419,000   2.326%
   GAM Exempt Trust - UK Opportunities                    4,323,580   0.810%
   SJP GAM Managed - Life                                 1,370,233   0.257%
   SJP GAM Managed - Pension                              1,084,007   0.203%
   St. James Place Recovery Unit Trust                    8,115,104   1.520%
   Totals                                                29,857,684   5.592%


Proxy Voting:

10. Name of the proxy holder:

    Institutional Shareholder Services

11. Number of voting rights proxy holder will cease to hold:

    N/A

12. Date on which proxy holder will cease to hold voting rights:

    N/A

13. Additional information:

    None

14. Contact name:

    Andrew Wood

15. Contact telephone number:

    01865 783000




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