Interest In Shares

Oxford Biomedica PLC
18 December 2007


For Immediate Release                                           18 DECEMBER 2007
                                                                            


                              Oxford BioMedica PLC



Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached (ii):

Oxford BioMedica PLC


2. Reason for the notification (please state Yes/No): ( )

An acquisition or disposal of voting rights: ( Yes )

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: ( )

An event changing the breakdown of voting rights: ( )

Other (please specify) : ( )


3. Full name of person(s) subject to the notification obligation (iii):

Prudential plc group of companies


4. Full name of shareholder(s) (if different from 3.) (iv):

Prudential plc (parent company)

M&G Group Limited (wholly owned subsidiary of Prudential plc)

M&G Limited (wholly owned subsidiary of M&G Group Limited)

M&G Investment Management Limited (wholly owned subsidiary of M&G Limited)

M&G Securities Limited (wholly owned subsidiary of M&G Limited)

The Prudential Assurance Company Limited (wholly owned subsidiary of Prudential
plc)



5. Date of the transaction (and date on which the threshold is crossed or
reached if different) (v):

13 December 2007


6. Date on which issuer notified:

17 December 2007


7. Threshold(s) that is/are crossed or reached:

10%


8. Notified details:


A: Voting rights attached to shares

Class/type of shares if possible using   Situation previous to the Triggering
the ISIN CODE                                      transaction (vi)
                                                  Number of           Number of
                                                     shares       voting Rights
                                                                         (viii)
GB0006648157                                   52,943,339          52,943,339


Resulting situation after the triggering transaction (vii)
Class/type of          Number of Number of voting rights (ix) % of voting rights
shares if possible        shares
using the ISIN
CODE

                          Direct    Direct (x)  Indirect (xi)   Direct  Indirect
GB0006648157        54,488,025    54,488,025                   10.19%


B: Financial Instruments

Resulting situation after the triggering transaction (xii)
Type of     Expiration Exercise/       Number of voting rights that may  % of
financial   Date       Conversion      be acquired if the instrument is  voting
instrument  (xiii)     Period/Date     exercised/ converted.             rights
                       (xiv)


N/A                N/A             N/A                               N/A     N/A


Total (A+B)
                                   Number of                         % of voting
                               voting rights                              rights
                                54,488,025                               10.19%


9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable (xv):
                 Registered Holder                            Holding        %

Prudential plc   Total Notifiable Interest               54,488,025      10.19%
                 Norturst Nominee Ltd A/C MHF01             134,616
                 Nortrust Nominee Ltd A/C MKK01          30,342,543
                 Nortrust Noms Ltd                          124,000
                 PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
                 PRUCLT HSBC GIS NOM (UK) PPL AC          5,134,498

M&G Group Limited                                        54,488,025      10.19%
                 Norturst Nominee Ltd A/C MHF01             134,616
                 Nortrust Nominee Ltd A/C MKK01          30,342,543
                 Nortrust Noms Ltd                          124,000
                 PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
                 PRUCLT HSBC GIS NOM (UK) PPL AC          5,134,498

M&G Investment Management
Limited                                                  54,353,409      10.16%
                 Nortrust Nominee Ltd A/C MKK01          30,342,543
                 Nortrust Noms Ltd                          124,000
                 PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
                 PRUCLT HSBC GIS NOM (UK) PPL AC          5,134,498

M&G Limited                                              54,488,025      10.19%
                 Norturst Nominee Ltd A/C MHF01             134,616
                 Nortrust Nominee Ltd A/C MKK01          30,342,543
                 Nortrust Noms Ltd                          124,000
                 PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
                 PRUCLT HSBC GIS NOM (UK) PPL AC          5,134,498

M&G Securities Limited                                   30,477,159       5.70%
                 Norturst Nominee Ltd A/C MHF01             134,616
                 Nortrust Nominee Ltd A/C MKK01          30,342,543

The Prudential Assurance
Company Limited                                          23,886,866       4.46%
                 PRUCLT HSBC GIS NOM (UK) PAC AC         18,750,368
                 PRUCLT HSBC GIS NOM (UK) PPL AC          5,134,498



Proxy Voting:

10. Name of the proxy holder:

N/A


11. Number of voting rights proxy holder will cease to hold:

N/A



12. Date on which proxy holder will cease to hold voting rights:

N/A


13. Additional information:

N/A


14. Contact name:

Andrew Wood


15. Contact telephone number:

01865 783000



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