Re Biological Research Magnet

Oxford Instruments PLC 10 August 2000 Oxford Instruments Launches the World's Most Powerful Magnet for Biological Research Oxford Instruments plc, the advanced instrumentation company, announces today that it has developed and built the world's most powerful magnet suitable for use in biological research. The 900 MHz magnet will be used in NMR systems to carry out biological and medical research into the 3-dimensional structure of macromolecules such as DNA and proteins including insulin. Knowledge of these structures is essential for understanding the molecular basis of disease and developing new therapeutic drugs. With this powerful magnet, scientists will be able to see these molecules in greater detail than ever before. Development of the magnet confirms Oxford Instruments' position as a world leader in the production of superconducting magnets. The Company believes it is the first to develop a magnet of this size that is capable of producing reliable and consistent results. Magnets such as this are used in NMR systems by biotechnology, pharmaceutical and medical organisations involved in research projects. This work is carried out by both government and commercial organisations. Oxford Instruments is supplying the 900 MHz magnet to Varian, a leading supplier of NMR systems. Andrew Mackintosh, Chief Executive of Oxford Instruments, said: 'This is a great achievement for our team at Oxford Instruments, clearly demonstrating our world leading position in the design and manufacture of superconducting magnets. Biotechnology, pharmaceutical and medical research markets are demanding increasingly sophisticated tools to analyse molecular structures. Our 900MHz NMR magnet provides a step towards meeting this demand and the technological advances made to develop this product can be used to develop the next generation of superconductive magnets.' Ray Shaw, General Manager of Varian NMR Systems, said: 'The successful completion of the high resolution 900 MHz magnet by Oxford Instruments represents an impressive milestone achievement in NMR magnet development and will certainly be welcomed by NMR scientists who continue to tackle many challenging problems in structural biology.' Enquiries: Oxford Instruments plc 01865 881 437 Andrew Mackintosh Martin Lamaison Citigate Dewe Rogerson 020 7638 9571 Chris Barrie / Melanie York Notes to editors 1. Oxford Instruments Oxford Instruments is a global leader in advanced instrumentation. It is a recognised world leader in several technologies, including superconductivity and the creation of low temperatures and in neurological measurements. The Company's products are used all over the world for scientific research, industrial chemical analysis and quality control, semiconductor processing and healthcare. Its customers include most of the world's major international companies as well as the leading research institutes. 2. Varian Varian, Inc. is a world leader in scientific instruments and vacuum technologies, serving life science, healthcare, chemical, environmental, and industrial customers. It is a major supplier of NMR systems, analytical instrument solutions, vacuum products and services, and specialized contract electronics manufacturing. The company manufactures in 11 locations in North America, Europe, and the Pacific Rim and employs more than 3,600 employees. Varian, Inc. had 1999 sales of $599 million. Additional information about Varian, Inc. is available at www.varianinc.com 3. Nuclear Magnetic Resonance (NMR) Biochemists use High Resolution NMR for the detailed study of living things at molecular level. NMR works on the same principle as MRI imaging used for medial diagnosis, but using far stronger magnetic fields. NMR is one of the premier tools used by scientists to analyse the 3-dimensional structure of molecules. When molecules are placed in a strong magnetic field, their ability to absorb and transmit high frequency radio waves can be measured. Scientists can interpret these radio wave patterns and use them to reconstruct the structure and shape of independent molecules or more complex macromolecules. The stronger the magnetic field the greater the detail that can be used. The development of the 900 MHz magnet depended on devising new techniques for handling and creating stable, strong coils from advanced superconducting materials. The magnet stands 4 metres tall and is 2 meters in diameter with a 1 metre wide spiral staircase around the outside to allow easy access to the top of the magnet.
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