Director Shareholding

Proteome Sciences PLC
01 October 2004


                     Proteome Sciences plc (the 'Company')


                  Directors Interest in Shares of the Company


Following the recent AGM when shareholders approved new share related incentive
schemes, and the release yesterday of the company's half yearly results for the
six months ended 30 June 2004, the Company announces today that it has made the
following awards to its four Executive Directors.


Awards of nil cost options under the Company's Long Term Incentive Plan were
granted on 1st October 2004 and calculated at a price of 74 pence per share as
follows :

                       Face Value of the Share Award                 Number

C.D.J. Pearce                         £315,000                      425,675
Dr. S.C. Steiner                      £189,000                      255,405
A.J. Green                             £66,500                       89,865
A.J. Green*                            £70,000                       94,594
J.L. Malthouse                        £147,000                      198,648


*In the form of Inland Revenue Approved Enterprise Management Incentive nil cost
options.


In accordance with institutional guidelines and as stated in the circular to
shareholders regarding the share related incentives, awards to participants in
the Long Term Incentive Plan are dependent upon the Total Shareholder Return of
the Company against its comparator group and the underlying financial
performance of the Company measured over a three year period.


The performance criteria upon which the above awards have been made are as set
out in the circular to shareholders issued by the company on 30th June 2004. The
level of awards is also in line with the level set out in the circular.


1st October 2004


                      This information is provided by RNS
            The company news service from the London Stock Exchange