Holding(s) in Company

Provexis PLC
25 January 2008


TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1.  Identity of the issuer or the underlying issuer of existing shares to
    which voting rights are attached
    PROVEXIS PLC

2.  Reason for the notification (please tick the appropriate box or boxes)

    An acquisition or disposal of voting rights                       (X)

    An acquisition or disposal of financial instruments which may     ( )
    result in the acquisition of shares already issued to which
    voting rights are attached

    An event changing the breakdown of voting rights                  ( )

    Other (specify):                                                  ( )

3.  Full name of person(s) subject to the notification obligation:
    ANGLE Plc

4.  Full name of shareholder(s) (if different from 3.)
    ANGLE Technology Limited
    Progeny BioVentures

5.  Date of the transaction (and date on which the threshold is crossed
    or reached if different):
    Various dates ending 3 December 2007

6.  Date on which issuer notified:
    24/01/08

7.  Threshold(s) that is/are crossed or reached:
    Holding falling below by more than 1% of the issuer's total voting
    rights and capital in issue

8.  Notified details:

A. Voting rights attached to shares

Class/type of shares (if possible using the Ordinary (GB00B0923P27)
ISIN code)

Situation previous to  Resulting situation after the triggering transaction
   the triggering
     transaction
Number of    Number of    Number of    Number of voting       % of voting rights
Shares       Voting       shares       rights
             Rights
                          Direct       Direct     Indirect    Direct    Indirect
79,395,643   79,395,643   65,143,643   65,143,643             16.2%

B. Financial Instruments

Resulting situation after the triggering transaction
Type of       Expiration   Exercise/            Number of voting     % of voting
financial     date         Conversion Period/   rights that may      rights
instrument                 Date                 be acquired if
                                                the instrument is
                                                exercised/
                                                converted
 
Total (A+B)
Number of voting rights              % of voting rights
65,143,643                           16.2%

9.  Chain of controlled undertakings through which the voting rights and/
    or the financial instruments are effectively held, if applicable:

Proxy Voting:

10.  Name of the proxy holder:          N/A

11.  Number of voting rights proxy      N/A
     holder will cease to hold:

12.  Date on which proxy holder         N/A
     will cease to hold voting
     rights:

13.  Additional information:

14:  Contact name:                     Ian Griffiths

15.  Contact telephone number:         01483 295830




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