Holding(s) in Company

Provexis PLC
14 September 2007



TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1.  Identity of the issuer or the underlying issuer of existing shares to
    which voting rights are attached

    PROVEXIS PLC

2.  Reason for the notification (please tick the appropriate box or boxes)

    An acquisition or disposal of voting rights                       (X)

    An acquisition or disposal of financial instruments which may     ( )
    result in the acquisition of shares already issued to which
    voting rights are attached

    An event changing the breakdown of voting rights                  ( )

    Other (specify):                                                  ( )

3.  Full name of person(s) subject to the notification obligation:

    Credit Agricole Cheuvreux International Ltd

4.  Full name of shareholder(s) (if different from 3.)

    Credit Agricole Cheuvreux International Ltd

5.  Date of the transaction (and date on which the threshold is crossed
    or reached if different):

    11 Sept 2007

6.  Date on which issuer notified:

    13 Sept 2007

7.  Threshold(s) that is/are crossed or reached:
    Holding after transaction went through percentage threshold

8.  Notified details:

A. Voting rights attached to shares

Class/type of shares (if possible using the            Ordinary (GB00B0923P27)
ISIN code)

Situation previous   Resulting situation after the triggering transaction
to the triggering
transaction

Number of   Number of  Number of    Number of voting      % of voting rights
Shares      Voting     shares       rights
            Rights
                       Direct       Direct    Indirect    Direct  Indirect
                       15,000,000   15,00,000             3.74%

B. Financial Instruments

Resulting situation after the triggering transaction
Type of       Expiration   Exercise/          Number of voting  % of voting
financial     date         Conversion Period/ rights that may   rights
instrument                 Date               be acquired if
                                              the instrument is
                                              exercised/
                                              converted

Total (A+B)
Number of voting rights              % of voting rights

15,000,000                           3.74%

9.  Chain of controlled undertakings through which the voting rights and/
    or the financial instruments are effectively held, if applicable:

    SAS Rue la Boetie
    Credit Agricole SA
    Calyon SA
    Credit Agricole Cheuvreux SA  15,000,000 3.74%

Proxy Voting:

10.  Name of the proxy holder:

11.  Number of voting rights proxy
     holder will cease to hold:

12.  Date on which proxy holder
     will cease to hold voting
     rights:


13.  Additional information:

14:  Contact name:                 Karen Browne

15.  Contact telephone number:     020 7214 5282




                      This information is provided by RNS
            The company news service from the London Stock Exchange