Product endorsement agreement

Provexis PLC 29 July 2005 PROVEXIS PLC ('Provexis' or the 'Company') Provexis and HEART UK enter product endorsement agreement Provexis, the nutraceutical company that develops scientifically proven functional and medical foods, is delighted to announce their entry into an initial three-year agreement with the registered heart health charity, HEART UK, which will see formal approval of the Company's lead product, the fruit juice drink Sirco(TM). In addition the two organisations will collaborate in research and educational activities designed to increase awareness of family heart health issues amongst the public. Sirco(TM), carrying the HEART UK logo, will initially be available in two flavours and the Company is currently planning, with major retailers, a national UK launch. The Sirco(TM) packaging will show that the product 'Helps to maintain a healthy heart and benefits the circulation.' Sirco(TM) contains the patented natural fruit extract called Fruitflow(TM). Fruitflow(TM) was discovered at the Rowett Research Institute in 1998 and since 2000 has been developed and clinically tested in human trials by Provexis. Fruitflow(TM) contains a range of tasteless tomato-derived natural compounds which have been proven to inhibit platelet aggregation, a part of the blood- clotting process which can cause heart attack and stroke. According to the British Heart Foundation, heart and circulatory disease is the UK's biggest killer. Sirco(TM) is being launched into a new, emerging category in the UK: 'heart-healthy' functional juices. This category first emerged in the US in the last two years, with rapid growth to 2004 sales of $100.1m, according to Information Resources Inc. data. Dr Stephen Franklin, Chief Executive Officer of Provexis, said: 'The approval granted by HEART UK is excellent news, and we look forward to working together in a proactive manner to promote heart health. Our strategy is to differentiate ourselves in the functional food industry by investing in R&D and developing products that taste great, deliver proven health benefits, and carry credible health claims supported by strong scientific proof.' Michael Livingston, the Director of HEART UK said: 'The Charity is delighted to be embarking on a long-term partnership with Provexis plc to help people take proactive steps to reduce their risk of heart disease.' Ends For further information please contact: Provexis plc Dr Stephen Franklin, CEO 07710 348 774 Bell Pottinger Corporate and Financial Ann-Marie Wilkinson/Emma Kent 020 7861 3232 Notes to Editors Provexis develops scientifically proven functional and medical foods. Functional foods are foods such as Benecol and Flora pro.activ that contain physiologically active food components and provide health benefits beyond basic nutrition. In June 2005 the Company joined AIM via a reverse takeover by Nutrinnovator. Nutrinnovator came into operation in February 2003 and launched the Altu nutrition bar, floated on AIM in June 2004 and brings with it a technology pipeline as well as marketing, selling and business development skills. Provexis was formed in December 1999 by the life-science subsidiary of the venture-management company, ANGLE plc. In January 2000, Provexis entered into a new technology option agreement with Rowett Research Services Ltd. (RRS), the commercial subsidiary of the Aberdeen based Rowett Institute, and this option was exercised in November 2001. Provexis' agreements with RRS have provided it with the intellectual property rights pertaining to its lead product, Fruitflow. Provexis continues to have strong links with the Rowett Institute, which provides the company with R&D facilities, human trials and, potentially, new technologies. HEART UK is a national charity of patients and their families, supporting research and helping to increase awareness and understanding of the importance of Heart Health and how to maintain a healthy cardiovascular system. HEART UK works with patients and their families and combines the rich skills of research scientists, the caring knowledgeable attention of doctors, nurses and dietitians, in order to support all those at risk of cardiovascular disease. Product Overview The company has an initial pipeline of four products in development: • Fruitflow(TM) - a proprietary tomato extract proven to reduce platelet aggregation which reduces the risk of thrombosis, a major cause of heart attack and stroke • Plantain extract - for digestive health and management of inflammatory bowel disease • Superbroccoli - broccoli based extract for the reduction of risk of specific cancers • Omega III oil technology - for heart-health and cognitive benefits The Fruitflow(TM) intellectual property rights are broad and well protected, and the product has been granted patent in Europe and Australia, and has a patent grant pending in the US. This information is provided by RNS The company news service from the London Stock Exchange

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