QIAGEN and Institute for Animal Health Enter Pa...
Worldwide license agreement expands the Company's veterinary assay
portfolio and aims to contain future outbreaks of the devastating
viral disease
Venlo, The Netherlands - November 6, 2008 - QIAGEN N.V. (NASDAQ:
QGEN; Frankfurt Prime Standard: QIA) has announced today that it has
entered into a worldwide exclusive partnership with the Institute for
Animal Health (IAH), a leading research and diagnostics institution
for infectious diseases of farm animals. Pursuant to the agreement
QIAGEN has licensed a novel molecular assay design for bluetongue, a
devastating viral disease among ruminants such as sheep and cattle.
The cador BTV RT-PCR Kit, which was developed by the IAH, will be
launched by QIAGEN in 2009 and further expand the company's
veterinary testing portfolio.
Bluetongue is caused by the bluetongue virus (BTV). It mainly
afflicts cattle and sheep which exhibit the highest morbidity and
mortality rates reaching up to 70 percent. Since 1998, the disease
has been rapidly spreading throughout Europe with outbreaks in most
countries including the United Kingdom, Spain, Italy, Greece,
Belgium, The Netherlands, Germany and France. In 2008 alone, 16
outbreaks of the disease have been registered across Europe.
Currently authorities in the Netherlands and several other countries
in Europe are struggling to contain outbreaks caused by a BTV type 8,
previously only found in Central and South America, and Africa. The
IAH estimates the potential economic impact of a major bluetongue
outbreak to exceed ¤ 600 million in the U.K. alone - resulting from
increased mortality rates, losses in milk production, export and
animal movement restrictions. Containment and therefore early
detection tools are key to combat this disease.
The new cador BTV RT-PCR Kit allows fast and highly sensitive
detection of all 24 known strains of the bluetongue virus; including
BTV-6 which has caused the latest outbreak of the disease in the
Netherlands, and BTV-1, which has spread from North Africa, up to the
north coast of France, threatening the UK. Because many symptoms of
bluetongue are not specific to the disease, there is a growing demand
for reliable and fast laboratory tests which might help to contain
future outbreaks.
"The emergence and dissemination of new BTV strains currently
observed in Europe pose a serious threat to the agricultural
industry. The new cador BTV RT-PCR can help to contain future
outbreaks of the disease, and thereby minimize the risk of major
economic damage", explains Simone Gauch, Global Marketing Director
Applied Testing at QIAGEN. "A major advantage of the test is that it
detects all known serotypes of the virus as well as variants from
different parts of the world. The test can be used to test
vaccinated animals, which are usually only protected against the
limited number of BTV types addressed by the vaccine, and thus
animals still need to be screened as soon as they exhibit any
symptoms. This has been impossible using traditional diagnostic
methods, because the antibodies present in vaccinated animals are too
similar to antigens produced during a new infection. Molecular
testing solutions such as the cador BTV RT-PCR assay eliminate this
loophole."
"The combination of IAH know-how in bluetongue testing with QIAGEN's
cutting-edge sample preparation and assay technologies creates a new
powerful diagnostic tool to quickly identify infected animals and
thus help to contain bluetongue outbreaks that are likely to occur in
the future", said Prof. Peter Mertens, Head of the Arbovirus Research
Group at the IAH. "Given QIAGEN's track record in molecular testing
and its global reach, the company was a partner of choice to bring
this technology to the international markets in order to fight this
costly disease."
QIAGEN's veterinary testing business is organized as part of QIAGEN's
Applied Testing Section which also includes rapidly growing
application areas such as forensics, biodefense, quality control and
others. In 2006, the company has entered into a licensing agreement
with the British Veterinary Laboratories Agency (VLA), thereby
allowing QIAGEN to enter the fast growing market for veterinary tests
with validated assays. Today, QIAGEN's veterinary portfolio
encompasses a broad range of sample and assay technologies, including
tests for Avian Flu, Bovine Viral Diarrhea (BVDV) and Taylorella
equigenitalis.
About BTV
Bluetongue is a hemorrhagic viral disease affecting sheep, cattle and
other ruminants. The disease spreads mainly via midges, which serve
as carrier for the currently 24 known strains of the bluetongue
virus. Following an incubation period of 5 to 20 days, infected
animals can exhibit symptoms such as fever, excessive loss of weight
and swelling of the muzzle, eyelids and ears. The mucosal surfaces of
the mouth become inflamed and ulcerated. The swellings can result in
insufficient oxygen supply to the affected tissues; the tongue
thereby develops a characteristic blue or purple color that gives the
disease its name. The mortality rate depends on many factors
including the animal's breed, age, its health status and the strain
of the virus. There is no treatment for bluetongue. Since 1998 the
distribution of BTV has changed significantly with multiple serotypes
of the virus spreading across Europe and into the South-eastern
United States. These events have been linked to climate change and
its effect on the insects (biting midges) involved in the
transmission of these viruses.
About IAH
The IAH delivers high quality fundamental, strategic and applied
science focused on infectious diseases of farm animals. This
knowledge is used to advance veterinary science, and to enhance the
sustainability of livestock farming. In addition to research output
the IAH provides diagnostic services for a number of diseases and
give expert advice to the UK government and international agencies.
IAH is the diagnostic laboratory for bluetongue in the UK, and is the
Reference Laboratory for bluetongue for the EU and the World
Organisation for Animal Health (OIE). More information can be found
at
http://www.iah.ac.uk.
About QIAGEN:
QIAGEN N.V., a Netherlands holding company, is the
leading global provider of sample and assay technologies. Sample
technologies are used to isolate and process DNA, RNA and proteins
from biological samples such as blood or tissue. Assay technologies
are used to make such isolated biomolecules visible. QIAGEN has
developed and markets more than 500 consumable products as well as
automated solutions for such consumables. The company provides its
products to molecular diagnostics laboratories, academic researchers,
pharmaceutical and biotechnology companies, and applied
testing customers for purposes such as forensics, animal or food
testing and pharmaceutical process control. QIAGEN's assay
technologies include one of the broadest panels of molecular
diagnostic tests available worldwide. This panel includes the only
FDA-approved test for human papillomavirus (HPV), the primary cause
of cervical cancer. QIAGEN employs more than 2,800 people in over 30
locations worldwide. Further information about QIAGEN can be found at
www.qiagen.com.
Certain of the statements contained in this news release may be
considered forward-looking statements within the meaning of Section
27A of the U.S. Securities Act of 1933, as amended, and Section 21E
of the U.S. Securities Exchange Act of 1934, as amended. To the
extent that any of the statements contained herein relating to
QIAGEN's products, markets, strategy or operating results are
forward-looking, such statements are based on current expectations
that involve a number of uncertainties and risks. Such uncertainties
and risks include, but are not limited to, risks associated with
management of growth and international operations (including the
effects of currency fluctuations and risks of dependency on
logistics), variability of operating results, the commercial
development of the applied testing markets, clinical research markets
and proteomics markets, women's health/HPV testing markets, nucleic
acid-based molecular diagnostics market, and genetic vaccination and
gene therapy markets, changing relationships with customers,
suppliers and strategic partners, competition, rapid or unexpected
changes in technologies, fluctuations in demand for QIAGEN's,
products (including fluctuations due to the level and timing of
customers' funding, budgets, and other factors), our ability to
obtain regulatory approval of our infectious disease panels,
difficulties in successfully adapting QIAGEN's products to integrated
solutions and producing such products, the ability of QIAGEN to
identify and develop new products and to differentiate its products
from competitors' products, market acceptance of QIAGEN's new
products and the integration of acquired technologies and businesses.
For further information, refer to the discussions in reports that
QIAGEN has filed with, or furnished to, the U.S. Securities and
Exchange Commission (SEC).
Contacts:
QIAGEN
Public Relations Investor Relations
Dr. Thomas Theuringer Dr. Solveigh Mähler
Tel: +49-2103-29-11826 Tel.: +49-2103-29-11710
Email: pr@qiagen.com Email: ir@qiagen.com
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