QIAGEN Introduces Comprehensive Solution for Ep...
Expanded EpiTect portfolio targets growing demand for standardized
sample and assay technologies to investigate processes regulating
gene function
Venlo, The Netherlands - June 18, 2008 - QIAGEN (NASDAQ: QGEN;
Frankfurt, Prime Standard: QIA) today announced a significant
expansion of its EpiTect product portfolio for epigenetics, one of
the most dynamic areas in life sciences. With the five new products,
QIAGEN now offers standardized solutions covering all steps of
epigenetic research processes in molecular diagnostics, pharma and
life sciences. By removing existing bottlenecks in epigenetic
research, the new products are expected to advance progress in the
development of new diagnostics and therapeutics for cancer and other
diseases.
Epigenetics focuses on the study of various phenomena which are
linked to the genome but do not result from genetic variability. One
of the major mechanisms which has been identified to regulate gene
expression is a chemical modification of the DNA called DNA
methylation, acting like an "on" and "off" switch for genes. As DNA
methylation is believed to play a major role in many diseases, in
particular cancers, epigenetic research holds great promise for the
development of novel biomarkers in diagnostics and for therapeutics.
Scientific progress has been hindered by a lack of standardized
methods and incompatibilities between technologies employed. QIAGEN
is now removing these barriers with the expansion of its EpiTect
product line, providing its customers in molecular diagnostics,
pharma and life sciences with complete pre-analytical and analytical
workflow solutions which guarantee reproducible results even from
scarce tissue samples and highest quality of downstream applications.
Epigenetic research has recently gained significant momentum leading
to many stunning discoveries. Discoveries show that various cell
types have unique patterns of DNA methylation, thus providing an
explanation for the transformation of stem cells to various tissue
types in the human body. In addition, research demonstrates that
methylation patterns can change over time as a reaction to
environmental conditions and are also hereditary. That way, the
behaviour of an individual - e.g. his nutrition uptake - can have an
influence on future generations.
The overall market for epigenetic applications is currently estimated
to grow at an annual compound growth rate of 60 percent and to exceed
US$ 4 Billion by 2012. Thereby, research primarily aims to deepen our
understanding of the highly sophisticated epigenetic regulation
mechanism and to develop new therapeutics targeting and diagnostics
incorporating DNA methylation patterns as highly sensitive and
specific biomarkers.
"Epigenetics is an extremely dynamic area of research and an
important market for QIAGEN," said Gerald Schock, Global Product
Manager WGA Epigenetics at QIAGEN. "Our expanded portfolio brings a
new level of efficiency, convenience and reliability to epigenetic
research and will help to further advance and disseminate epigenetic
applications by removing key bottlenecks previously hindering the
corresponding research work."
At an early stage, QIAGEN recognized the growing market demand for
specific, standardized sample and assay technologies for epigenetic
research and launched its first product in 2006, establishing a new
standard for sample processing for DNA methylation analysis. The
expanded product offering includes a novel technology
representatively amplifying specifically treated DNA needed for the
methylation analysis, allowing researchers to perform multiple tests
from limited sample material. Moreover, these products include a
real-time PCR based test-kit for the quantitative analysis of
methylated DNA, assays for differentiation of methylated DNA in genes
related to cancer and a novel PCR based technology which
significantly improves accuracy of qualitative analysis of methylated
DNA. Finally, the portfolio includes control DNAs used to verify
methylation analysis, thus increasing standardization in assay
setups.
About DNA methylation
The ability to detect and quantify DNA methylation efficiently and
accurately is an essential tool for scientists to study the role of
epigenetic changes in cancer and other serious diseases, as well as
many other clinical applications. Methylation is a natural process
that occurs when cytosine, one of the DNA's four bases, will be
modified with a methyl group. The presence of methylation is
responsible for controlling the activity of genes by turning them
off, like a switch, when not needed. By measuring the differences in
the methylation patterns between healthy and diseased tissue, a
change in gene activity as an early prognostic biomarker that could
trigger diseases, such as cancer, can be detected.
About QIAGEN:
QIAGEN N.V., a Netherlands holding company, is the
leading global provider of sample and assay technologies. Sample
technologies are used to isolate and process DNA, RNA and proteins
from biological samples such as blood or tissue. Assay technologies
are used to make isolated biomolecules visible for study. QIAGEN has
developed and markets more than 500 consumable products as well as
automated solutions. The company provides its products to molecular
diagnostics laboratories, academic researchers, pharmaceutical and
biotechnology companies, and applied testing customers for
purposes such as forensics, animal or food testing and pharmaceutical
process control. QIAGEN's assay technologies include one of the
broadest panels of molecular diagnostic tests available worldwide.
This panel includes the only FDA-approved test for human
papillomavirus (HPV), the primary cause of cervical cancer. QIAGEN
employs more than 2,700 people in over 30 locations worldwide.
Further information about QIAGEN can be found at www.qiagen.com.
Certain of the statements contained in this news release may be
considered forward-looking statements within the meaning of Section
27A of the U.S. Securities Act of 1933, as amended, and Section 21E
of the U.S. Securities Exchange Act of 1934, as amended. To the
extent that any of the statements contained herein relating to
QIAGEN's products, markets, strategy or operating results are
forward-looking, such statements are based on current expectations
that involve a number of uncertainties and risks. Such uncertainties
and risks include, but are not limited to, risks associated with
management of growth and international operations (including the
effects of currency fluctuations and risks of dependency on
logistics), variability of operating results, the commercial
development of the applied testing markets, clinical research markets
and proteomics markets, women's health/HPV testing markets, nucleic
acid-based molecular diagnostics market, and genetic vaccination and
gene therapy markets, changing relationships with customers,
suppliers and strategic partners, competition, rapid or unexpected
changes in technologies, fluctuations in demand for QIAGEN's,
products (including fluctuations due to the level and timing of
customers' funding, budgets, and other factors), our ability to
obtain regulatory approval of our infectious disease panels,
difficulties in successfully adapting QIAGEN's products to integrated
solutions and producing such products, the ability of QIAGEN to
identify and develop new products and to differentiate its products
from competitors' products, market acceptance of QIAGEN's new
products and the integration of acquired technologies and businesses.
For further information, refer to the discussions in reports that
QIAGEN has filed with, or furnished to, the U.S. Securities and
Exchange Commission (SEC).
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Contacts:
Dr. Solveigh Mähler Dr. Thomas Theuringer
Director Investor Relations Associate Director Public
QIAGEN N.V. Relations
+49 2103 29 11710 QIAGEN GmbH
e-mail: +49 2103 29 11826
solveigh.maehler@qiagen.com email:
thomas.theuringer@qiagen.com
Albert F. Fleury
Investor Relations North America
QIAGEN N.V.
+1 301 944 7028
e-mail: albert.fleury@qiagen.com