QIAGEN Launches Novel Product Enabling Non-Inva...
QIAamp kit sets new standard for the extraction of free circulating
DNA and
RNA fragments in human blood
Venlo, The Netherlands, May 25, 2009 --- QIAGEN today announced the
launch of a novel product for extraction of free circulating
fragments of tumor- and fetal-derived nucleic acids as well as viral
nucleic acids in human blood. Scientists consider these DNA and RNA
fragments to have great potential for the highly sensitive and
non-invasive diagnosis of a wide range of diseases, including
congenital disorders, malignancies such as colon and lung cancer, and
infections. The new QIAamp Circulating Nucleic Acid Kit is expected
to significantly facilitate the corresponding biomarker research and
the introduction of novel molecular tests in prenatal diagnostics
which can replace risky, invasive procedures such as amniocentesis.
Free circulating DNA and RNA fragments are found in body fluids such
as plasma, serum and urine. Scientific research has demonstrated that
plasma, in particular, carries a variety of nucleic acids from
viruses and different tissues throughout the body, including
developing fetuses and tumors. In cancer research, it has also been
shown that the concentration of tumor DNA fragments is related to the
extent of the disease. The analysis of such DNA and RNA fragments
thus not only enables new, virtually non-invasive approaches to the
early and highly sensitive detection of different malignancies such
as colon or lung cancer, but can also help to monitor the progress of
the disease and to assess patient outcomes. Likewise, fetal DNA and
RNA fragments circulating in maternal blood can be used for
the non-invasive molecular detection of congenital disorders in
prenatal diagnostics, an area where QIAGEN also cooperates with
Sequenom, Inc. which is a leader in this field.
QIAGEN's new QIAamp Circulating Nucleic Acid Kit for the first time
enables the isolation and purification of all types and all sizes of
nucleic acids from large-scale plasma and serum samples - and thereby
enables unprecedented yields of the isolated molecules and the
highest sensitivity of downstream applications. This significantly
facilitates the molecular detection of viral infections, where
extraction of even the scarcest traces of genetic material is a key
requirement for reliable results. Moving forward, the company plans
to extend the use of the product to urine samples and the isolation
of free circulating miRNA molecules from plasma and serum, which can
serve as highly specific biomarkers for cancer.
"Our new product brings major improvements to biomarker research for
cancer and the development of novel, virtually non-invasive
diagnostics based upon nucleic acid fragments circulating in body
fluids", said Uwe Oelmueller, Senior Director R&D Diagnostic Sample
Preparation and Stabilization at QIAGEN. "The clinical value of this
method is well documented, but its widespread implementation and
progress in further research have been hampered by the cumbersome and
demanding methodology for handling such molecules. The new QIAamp kit
removes this bottleneck and will bring significant value for
researchers and clinicians."
The novel kit is currently available for research use only. The
company plans to validate the product for in-vitro diagnostic
applications in the United States and Europe.
About QIAGEN:
QIAGEN N.V., a Netherlands holding company, is the
leading global provider of sample and assay technologies. Sample
technologies are used to isolate and process DNA, RNA and proteins
from biological samples such as blood or tissue. Assay technologies
are used to make such isolated biomolecules visible. QIAGEN has
developed and markets more than 500 sample and assay products as well
as automated solutions for such consumables. The company provides its
products to molecular diagnostics laboratories, academic researchers,
pharmaceutical and biotechnology companies, and applied
testing customers for purposes such as forensics, animal or food
testing and pharmaceutical process control. QIAGEN's assay
technologies include one of the broadest panels of molecular
diagnostic tests available worldwide. This panel includes the digene
HPV Test, which is regarded as the "gold standard" in testing for
high-risk types of human papillomavirus (HPV), the primary cause of
cervical cancer. QIAGEN employs more than 3,100 people in over 30
locations worldwide. Further information about QIAGEN can be found at
http://www.qiagen.com/.
Statements contained in this release that are not historical facts
are forward-looking statements, including statements about our
products, markets, strategy and operating results. Such statements
are based on current expectations that involve risks and
uncertainties including, but not limited to, those associated with:
management of growth and international operations (including currency
fluctuations and logistics), variability of our operating results,
commercial development of our markets (including applied testing,
clinical and academic research, proteomics, women's health/HPV
testing and molecular diagnostics), our relationships with customers,
suppliers and strategic partners, competition, changes in technology,
fluctuations in demand, regulatory requirements, identifying,
developing and producing integrated products differentiated from our
competitors' products, market acceptance of our products, and
integration of acquired technologies and businesses. For further
information, refer to our filings with the SEC, including our latest
Form 20-F. Information in this release is as of the date of the
release, and we undertake no duty to update this information unless
required by law.
Contacts:
Public Relations Investor Relations
Dr. Thomas Theuringer Dr. Solveigh Maehler
Associate Director Public Relations Director Investor Relations
+49 2103 29 11826 +49 2103 29 11710
Nicole York Albert F. Fleury
Communications Manager North Investor Relations North
America America
+ 1 240 686 7660 +1 301 944 7028
email: pr@qiagen.com Email: ir@qiagen.com
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