Re: New Data

ReNeuron Group plc 31 May 2007 ReNeuron announces new data concerning its ReNcell(R) neural stem cell lines Guildford, UK, 31 May 2007: ReNeuron Group plc (LSE: RENE.L) today announces new data concerning its ReNcell(R)CX and ReNcell(R)VM neural cell lines. These cell lines are marketed through Millipore Corporation as drug discovery tools for academic and commercial research. The data were generated in collaboration with Drs Roberta Donato and Frances Edwards at the Department of Physiology, University College London (UCL). The results demonstrate that the ReNcell(R)CX and ReNcell(R)VM lines can be continuously expanded in monolayer culture and will differentiate into the three principal neural cell types: neurons, astrocytes and oligodendrocytes. In the case of the ReNcell(R)VM line, a renewable source of stable, functional and electrophysiologically active dopaminergic neurons was demonstrated. The results are published in the on-line journal, BMC Neuroscience (http://www.biomedcentral.com/1471-2202/8/36/abstract) Dr John Sinden, Chief Scientific Officer of ReNeuron, said: 'We are pleased to have further validated the utility of our first generation ReNcell neural cell lines through this collaboration with UCL. The ability of the ReNcell(R) lines to functionally differentiate in vitro makes them potentially powerful research tools in the discovery of new therapies targeting diseases of the central nervous system, including Parkinson's Alzheimer's and Huntington's diseases as well as schizophrenia and depression.' Enquiries: ReNeuron Michael Hunt, Chief Executive Officer Tel: +44 (0) 1483 302560 Dr John Sinden, Chief Scientific Officer Financial Dynamics David Yates Tel: +44 (0) 20 7831 3113 Nicola Daley Notes to Editors ReNeuron is a leading, UK-based stem cell therapy business. It is applying its novel stem cell platform technologies in the development of ground-breaking stem cell therapies to serve significant and unmet or poorly-met clinical needs. ReNeuron has used its c-mycER technology to generate genetically stable neural stem cell lines. This technology platform has multi-national patent protection and is fully regulated by means of a chemically-induced safety switch. Cell growth can therefore be completely arrested prior to in vivo implantation. ReNeuron has filed for approval to commence initial clinical studies in the US with its lead ReN001 stem cell therapy for chronic stroke disability. This represents the world's first such filing concerning a neural stem cell treatment for a major neurological disorder. ReNeuron has also generated pre-clinical efficacy data with its ReN005 stem cell therapy for Huntington's disease, a genetic and fatal neurodegenerative disorder that affects around 1 in 10,000 people. This programme is in pre-clinical development. In addition to its stroke and Huntington's disease programmes, ReNeuron is developing stem cell therapies for Parkinson's disease, Type 1 diabetes and diseases of the retina. ReNeuron has also leveraged its stem cell technologies into non-therapeutic areas - its ReNcell(R) range of cell lines for use in research and in drug discovery applications in the pharmaceutical industry. ReNeuron's ReNcell(R)CX and ReNcell(R)VM neural cell lines are marketed worldwide under license by Millipore Corporation. ReNeuron's shares are traded on the London AIM market under the symbol RENE.L. Further information on ReNeuron and its products can be found at www.reneuron.com. Data sources: UK Stroke Association; American Stroke Association. This announcement contains forward-looking statements with respect to the financial condition, results of operations and business achievements/performance of ReNeuron and certain of the plans and objectives of management of ReNeuron with respect thereto. These statements may generally, but not always, be identified by the use of words such as 'should', 'expects', 'estimates', 'believes' or similar expressions. This announcement also contains forward-looking statements attributed to certain third parties relating to their estimates regarding the growth of markets and demand for products. By their nature, forward-looking statements involve risk and uncertainty because they reflect ReNeuron's current expectations and assumptions as to future events and circumstances that may not prove accurate. A number of factors could cause ReNeuron's actual financial condition, results of operations and business achievements/performance to differ materially from the estimates made or implied in such forward-looking statements and, accordingly, reliance should not be placed on such statements. The terms 'ReNeuron', 'the Company' or 'the Group' used in this statement refer to ReNeuron Group plc and/or its subsidiary undertakings, depending on the context. This information is provided by RNS The company news service from the London Stock Exchange
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