Holding(s) in Company

Aortech International PLC
04 April 2008


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Identity of the issuer or the underlying issuer of existing shares to which
   voting rights are attached (ii):

   AorTech International plc

2. Reason for the notification (please state Yes/No): ( )

   An acquisition or disposal of voting rights: (Yes )
   An acquisition or disposal of financial instruments which may result in the
   acquisition of shares already issued to which voting rights are attached: ( )
   An event changing the breakdown of voting rights: ( )
   Other (please specify): ( )

3. Full name of person(s) subject to the notification obligation (iii):

   GAM International Management Limited

4. Full name of shareholder(s) (if different from 3.) (iv):



5. Date of the transaction (and date on which the threshold is crossed or
   reached if different) (v):

   26 March 2008

6. Date on which issuer notified:

   28 March 2008

7. Threshold(s) that is/are crossed or reached:

   Fallen below 3%


8. Notified details:



A: Voting rights attached to shares

Class/type of shares Situation previous to the Triggering transaction
if possible using                          (vi)
the ISIN CODE
                      Number of shares  Number of voting Rights (viii)
GB0033360586                   196,077                         196,077


Resulting situation after the triggering transaction (vii) Less than 3%

Class/type of       Number of      Number of voting    % of voting rights
shares if            shares           rights (ix)
possible using
the ISIN CODE

                          Direct    Direct    Indirect     Direct Indirect
                                       (x)        (xi)
GB0033360586              55,590    55,590                  1.15%

B: Financial Instruments

Resulting situation after the triggering transaction (xii)
Type of     Expiration Date  Exercise/Conversion Number of voting     % of voting
financial   (xiii)           Period/Date (xiv)   rights that may be   rights
instrument                                       acquired if the
                                                 instrument is
                                                 exercised/
                                                 converted.
N/A         N/A              N/A                 N/A                  N/A


Total (A+B)
 Number of voting rights  % of voting rights
                  55,590               1.15%


9. Chain of controlled undertakings through which the voting rights and/or the
   financial instruments are effectively held, if applicable (xv):

   GAM International Management Limited is the discretionary investment manger for
   the following:

+------------------------+----------------+--------------------+---------------+
|Fund Name               |Last Trade Date |Nominal             |% of Issue     |
+------------------------+----------------+--------------------+---------------+
|GAM Star UK Dynamic     |28 January 2008 |55,590.00           |1.150          |
|Equity Investments      |                |                    |               |
|                        |                |                    |               |
+------------------------+----------------+--------------------+---------------+
|GAM UK Equity Hedge     |26 March 2008   |0.00                |0.000          |
|Investments Inc.        |                |                    |               |
+------------------------+----------------+--------------------+---------------+


Period of Interest        18 March 2008 to 28 March 2008
Security                  AorTech International plc GBP2.50
ISIN                      GB0033360586
SEDOL                     3336058
Uptix Code                3336058
Number of shares in issue 4,832,778.00


Proxy Voting:

10. Name of the proxy holder:

    Institutional Shareholder Services

11. Number of voting rights proxy holder will cease to hold:

    n/a

12. Date on which proxy holder will cease to hold voting rights:

    n/a

13. Additional information:

    n/a

14. Contact name:

    n/a

15. Contact number:

    n/a


Annex to Notification Of Major Interests In Shares (xvi)


A: Identity of the person or legal entity subject to the notification obligation


Full name (including legal form for legal entities):

GAM International Management Limited

Contact address (registered office for legal entities):

12 St James's Place, London SW1A 2NX

Phone number:

020 7917 2346

Other useful information (at least legal representative for legal persons):



B: Identity of the notifier, if applicable (xvii)


Full name:

Kemi Thomas

Contact address:

As above

Phone number:

As above

Other useful information (e.g. functional relationship with the person or legal
entity subject to the notification obligation)

n/a




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