Holding(s) in Company

Smith & Nephew Plc
20 April 2006


                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

Smith & Nephew plc


2. Name of shareholder having a major interest

The Capital Group Companies, Inc.


3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Non-beneficial


4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Capital Guardian Trust Company:
State Street Nominees Ltd   82,550
Bank Of New York Nominees Ltd   1,377,243
Chase Manhattan Bank Australia Ltd   8,500
Chase Nominees Ltd   6,730,310
BT Globenet Nominees Ltd   137,300
Midland Bank plc   240,700
Cede & Co 140,500
Deutsche Bank Mannheim 4,500
Bankers Trust 49,200
Nortrust Nominees 1,371,174
MSS Nominees Ltd   31,700
State Street Bank & Trust Co  55,900
Deutsche Bank AG 3,600
HSBC Bank plc  2,900
ROY Nominees Ltd   4,600
Mellon Nominees (UK) Ltd   337,900
Bank One London   9,700
HSBC 5,200
JP Morgan Chase Bank   907,333

Capital International Ltd:
State Street Nominees Ltd   9,200
Bank of New York Nominees  923,106
Northern Trust   384,044
Chase Nominees Ltd   703,545
Midland Bank plc   22,900
Morgan Guaranty  77,500
Nortrust Nominees  570,726
State Street Bank & Trust Co   319,641
Citibank   101,600
Deutsche Bank AG   22,000
HSBC Bank plc  265,565
Mellon Bank NA 28,700
KAS UK 8,900
Bank One London  31,300
JP Morgan Chase Bank   10,800
Raiffeisen Zentral Bank   89,400
Fortis Bank   7,000
Metzler Seel Sohn & Co.   6,500
Nordea Bank   19,000
Bayerische Hypo Und Vereinsbank AG   9,600

Capital International SA:
Chase Nominees Ltd   112,600
Midland Bank plc 6,900
Lloyds Bank 5,200
HSBC Bank plc 38,400
Metzler Seel Sohn & Co.   10,200

Capital Research and Management Company:
State Street Nominees Ltd   17,890,800
Chase Nominees Ltd   89,013,589
State Street Bank & Trust Co 182,000

Capital International Inc
Nortrust Nominees 23,000
HSBC Bank plc 11,500


5. Number of shares / amount of stock acquired

Not disclosed


6. Percentage of issued class

Not disclosed


7. Number of shares / amount of stock disposed

...............................................................


8. Percentage of issued class

...............................................................


9. Class of security

Ordinary shares of US 20 cents


10. Date of transaction

Not known


11. Date company informed

20.04.06


12. Total holding following this notification

122,406,026


13. Total percentage holding of issued class following this notification

13.00%


14. Any additional information

...............................................................


15. Name of contact and telephone number for queries

Phil Higgins - Assistant Company Secretary
020 7960 2228


16. Name and signature of authorised company official responsible for making
this notification

Phil Higgins - Assistant Company Secretary


Date of notification

20.04.06


The FSA does not give any express or implied warranty as to the accuracy of this
document or material and does not accept any liability for error or omission.
The FSA is not liable for any damages (including, without limitation, damages
for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
any such material.



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