Holding(s) in Company

Smith & Nephew Plc
24 October 2005

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company

Smith & Nephew plc


2. Name of shareholder having a major interest

The Capital Group Companies, Inc.


3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Non-beneficial


4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Capital Guardian Trust Company:
State Street Nominees Ltd   82,550
Bank Of New York Nominees Ltd   1,292,143
Northern Trust  71,500
Chase Manhattan Bank Australia Ltd   8,500
Chase Nominees Ltd   6,713,313
BT Globenet Nominees Ltd   137,300
Midland Bank plc   194,900
Deutsche Bank Mannheim 4,500
Bankers Trust 9,200
Nortrust Nominees 1,558,540
Royal Bank of Scotland   12,000
MSS Nominees Ltd   31,700
State Street Bank & Trust Co  26,500
RBSTB Nominees Ltd    3,100
Deutsche Bank AG 3,600
HSBC Bank plc  600
ROY Nominees Ltd   6,600
Mellon Nominees (UK) Ltd   388,200
HSBC 5,200
JP Morgan Chase Bank   657,333

Capital International Ltd:

State Street Nominees Ltd   38,700
Bank of New York Nominees  925,465
Northern Trust   376,344
Chase Nominees Ltd   572,193
Midland Bank plc   22,900
Bankers Trust   48,100
Citibank London 120,600
Morgan Guaranty  77,500
Nortrust Nominees  803,826
Royal Bank of Scotland 89,400
State Street Bank & Trust Co   59,300
Deutsche Bank AG   252,541
HSBC Bank plc  241,265
Mellon Bank NA 50,200
KAS UK 8,900
Bank One London  31,300

Capital International SA:
Bank of New York Nominees 6,100
Chase Nominees Ltd   169,852
Midland Bank plc 2,400
Lloyds Bank 5,200
HSBC Bank plc 38,400

Capital Research and Management Company:

State Street Nominees Ltd   9,690,400
Chase Nominees Ltd   32,119,764


Capital International Inc

Nortrust Nominees 23,000
HSBC Bank plc 11,500

5. Number of shares / amount of stock acquired

Not disclosed


6. Percentage of issued class

Not disclosed


7. Number of shares / amount of stock disposed

...............................................................


8. Percentage of issued class

...............................................................


9. Class of security

Ordinary shares of 12 2/9p


10. Date of transaction

Not known


11. Date company informed

24.10.05


12. Total holding following this notification

57,111,429


13. Total percentage holding of issued class following this notification

6.09%


14. Any additional information

...............................................................


15. Name of contact and telephone number for queries

Phil Higgins - Assistant Company Secretary
020 7960 2228


16. Name and signature of authorised company official responsible for making
this notification

Phil Higgins - Assistant Company Secretary


Date of notification

24.10.05


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document or material and does not accept any liability for error or omission.
The FSA is not liable for any damages (including, without limitation, damages
for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
any such material.


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