Holding(s) in Company

Smith & Nephew Plc
04 November 2005

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company



Smith & Nephew plc



2. Name of shareholder having a major interest



The Capital Group Companies, Inc.



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18



Non-beneficial



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them


Capital Guardian Trust Company:

State Street Nominees Ltd   82,550
Bank Of New York Nominees Ltd   1,314,743
Northern Trust  71,500
Chase Manhattan Bank Australia Ltd   8,500
Chase Nominees Ltd   6,776,313
BT Globenet Nominees Ltd   137,300
Midland Bank plc   194,900
Cede & Co 119,000
Deutsche Bank Mannheim 4,500
Bankers Trust 9,200
Nortrust Nominees 1,633,140
Royal Bank of Scotland   12,000
MSS Nominees Ltd   31,700
State Street Bank & Trust Co  26,500
RBSTB Nominees Ltd    9,700
Deutsche Bank AG 3,600
HSBC Bank plc  600
ROY Nominees Ltd   6,600
Mellon Nominees (UK) Ltd   388,200
HSBC 5,200
JP Morgan Chase Bank   657,333



Capital International Ltd:

State Street Nominees Ltd   38,700
Bank of New York Nominees  909,265
Northern Trust   376,344
Chase Nominees Ltd   658,145
Midland Bank plc   22,900
Bankers Trust   48,100
Citibank London 130,200
Morgan Guaranty  77,500
Nortrust Nominees  803,826
Royal Bank of Scotland 96,400
State Street Bank & Trust Co   69,000
National Westminster Bank 10,800
Deutsche Bank AG   281,041
HSBC Bank plc  265,565
Mellon Bank NA 50,200
KAS UK 8,900
Bank One London  31,300



Capital International SA:

Bank of New York Nominees 6,100
Chase Nominees Ltd   83,900
Midland Bank plc 2,400
National Westminster Bank 10,200
Lloyds Bank 5,200
HSBC Bank plc 38,400





Capital Research and Management Company:
State Street Nominees Ltd   9,729,000
Chase Nominees Ltd   41,910,620
State Street Bank & Trust Co 118,200





Capital International Inc

Nortrust Nominees 23,000
HSBC Bank plc 11,500







5. Number of shares / amount of stock acquired



Not disclosed



6. Percentage of issued class



Not disclosed



7. Number of shares / amount of stock disposed



...............................................................



8. Percentage of issued class



...............................................................



9. Class of security



Ordinary shares of 12 2/9p



10. Date of transaction



Not known



11. Date company informed



04.11.05



12. Total holding following this notification



67,309,785



13. Total percentage holding of issued class following this notification



7.17%



14. Any additional information



...............................................................



15. Name of contact and telephone number for queries



Phil Higgins - Assistant Company Secretary

020 7960 2228



16. Name and signature of authorised company official responsible for making
this notification



Phil Higgins - Assistant Company Secretary



Date of notification



04.11.05



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for loss of business or loss of profits) arising in contract, tort or otherwise
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