New Licence Deal - Deltagen

Stem Cell Sciences plc 05 September 2005 5 September 2005 Stem Cell Sciences - New Licence Deal with Deltagen Stem Cell Sciences plc - the Edinburgh based stem cell research company - has today announced a major licensing agreement with U.S.-based Deltagen, Inc. for use of its patented IRES technology. In addition to an up-front licence fee of U.S.$1.2 million, the agreement includes royalties based on revenues generated by Deltagen. As part of the deal, Stem Cell Sciences will receive from Deltagen selected genetically engineered mice. This announcement follows the recent listing of Stem Cell Sciences (STEM) on the London Stock Exchange's Alternative Investment Market (AIM) and the subsequent granting of expanded claims for a key patent in relation to Stem Cell Selection in the US. The US is a major market in Stem Cell Sciences' expansion programme. The Deltagen agreement and the awarding of the extended patent claims in the US increases the base for future licensing deals in the important North American market. Deltagen becomes the first company licensed to use Stem Cell Sciences' IRES technology for the manufacture, sale and sub-licensing of 'knock-out' mice. Dr Peter Mountford, CEO of Stem Cell Sciences said; "We are very pleased to be expanding our business in bio-medical research. The human stem cell field is another exciting opportunity for the company and we are looking forward to further licensing deals for our IRES technology in this sector." Robert Driscoll, J.D., Ph.D., Vice President of Intellectual Property & Legal Affairs for Deltagen, Inc. said; "The granting of this licence ensures our ability to incorporate Stem Cell Sciences' powerful IRES technology into our full product range of knockout mouse-related materials." NOTES TO EDITORS: Stem cells are undifferentiated (un-specialised) cells which can divide to make copies of themselves or differentiate (change) to become specialised cells of a specific tissue such as neural cells or blood cells. IRES Technology (Internal Ribosome Entry Sites Technology) is a simple but highly versatile gene expression system used in cell-based drug screening and animal models of human diseases. Stem Cell Sciences hold patents over the use of IRES technology in stem cells and animal models. Knock-out mouse - where a mouse has been genetically engineered to be deficient in a specific gene to enable the study of that gene's function. This enables the creation of model organisms for the study of drug interactions by large pharmaceutical companies. Stem Cell Sciences plc ("SCS") is a global biotechnology company established in Melbourne in 1994 to undertake research on embryonic stem cell technologies. SCS operates as a collaborative group with research laboratories in Australia, Scotland and Japan, each of which is affiliated with an academic centre of excellence. SCS intends to establish operations in the US in 2006. The company's business model combines short-term revenue generating activities with the development of a pipeline of cell-based therapies. As a result of this approach, patients stand to benefit directly in the short term from the application of SCS technologies to drug discovery and in the longer term through access to cell-based therapeutics. Stem Cell Sciences listed on the London AIM exchange on 18 July 2005 (AIM: STEM). Deltagen, Inc is a leading provider of drug discovery tools and services to the biopharmaceutical industry. Deltagen offers a suite of programs designed to enhance the efficiency of drug discovery including access to biological models as well as both small-molecule and secreted protein drug targets. In addition, Deltagen offers extensive target validation data in the areas of immunology and metabolic diseases. Deltagen's products and programs have been validated by customers and partners such as Eli Lilly & Co., GlaxoSmithKline, Merck & Co., Millennium Pharmaceuticals and Pfizer. Issued on behalf of Stem Cell Sciences plc by Trimedia Communications. For further information contact: Nicky Hawkins T: + 44 (0)131 272 2715 M: + 44 (0)7733 124052 nicky.hawkins@trimediauk.com This information is provided by RNS The company news service from the London Stock Exchange

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