Symrise, BRAIN and AnalytiCon: A successful par...

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Symrise obtains  exclusive marketing  rights to  new cosmetic  active
ingredients  thanks  to  its   strategic  partnership  with   biotech
specialists - product launch planned for 2009


Holzminden/Zwingenberg/Potsdam, November 20, 2008  - Symrise, one  of
the world's  leading manufacturers  of fragrances  and flavorings  as
well as ingredients for cosmetics, has acquired licenses for two  new
groups of cosmetic active  ingredients. These promising results  were
achieved in a joint development project with biotech specialist BRAIN
and natural-product  company AnalytiCon.  The license  gives  Symrise
international marketing rights.

The goal of the  strategic partnership which  was initiated in  April
2007  was  to  jointly  develop  innovative  and  all-natural  active
ingredients for use  in cosmetics. "This  alliance allows Symrise  to
follow new paths in developing highly effective cosmetic  ingredients
and continuing  to  expand its  competence  in the  field  of  active
ingredients for  skin and  hair care,"  explains Gabriele  Vielhaber,
Vice President, Innovation R&D, Life Essentials.

By  June  30,  2008,  the  three  cooperation  partners  successfully
completed two  screening procedures  to identify  multiple groups  of
innovative active ingredients  thus enabling Symrise  to develop  new
active components for use in cosmetics.

As of October 1, 2008,  Symrise has acquired the exclusive  marketing
rights to two of these  groups of active ingredients. Clinical  tests
have proven the high  efficacy of both groups,  and Symrise will  now
develop them with the goal of a  market launch in 2009. They will  be
used primarily in deodorants as well as products for sensitive skin.

"Working with companies such as BRAIN and AnalytiCon, both leaders in
their fields,  has complemented  our own  R&D activities  and made  a
major contribution  to our  innovation  pipeline after  a  remarkably
short development phase," as  Achim Daub, head  of Symrise's Scent  &
Care division, says. "We will keep following this successful strategy
and are happy  to have established  such a powerful  alliance in  the
field of natural ingredients with these two outstanding partners."

Holger Zinke, CEO of  BRAIN, adds, "In only  18 months we managed  to
develop  two  `first-in-class'  products,  all  the  way  from  assay
development and high-throughput screening to in vivo efficacy  tests.
This demonstrates the  remarkable quality and  strength of our  joint
efforts."

"The trilateral cooperation between Symrise, BRAIN and AnalytiCon  is
an outstanding  example of  a successful  and efficient  division  of
labor and  networking among  specialized  partners. The  results  far
exceed our expectations," as  Lutz Müller-Kuhrt, head of  AnalytiCon,
comments.  "The  intense  cooperation  of  three  such  complementary
partners made us exceptionally  efficient in identifying,  optimizing
and  developing   innovative  active   ingredients  for   top-quality
cosmetics."
About Symrise
Symrise is  a  global  supplier of  fragrances,  flavorings  and  raw
materials and active ingredients for the perfume, cosmetics and  food
industry.
Its sales of ¤1.27  billion in 2007 place  the company among the  top
four  in   the   international   flavors   and   fragrances   market.
Headquartered in Holzminden, Germany, Symrise is represented in  more
than 30  countries  in Europe,  Asia,  the United  States  and  South
America.
With more than 40 first patent applications per year, Symrise is  one
of  the  most  innovative  manufacturers  on  the  market.  Used   by
manufacturers of perfumes, cosmetics and  foods, our products are  an
inseparable part of daily life. At Symrise we combine an awareness of
consumer  trends   with   cutting-edge  technologies,   focusing   on
innovative  fashion  and  lifestyle  products  that  have  additional
practical value for the consumer. Symrise - always inspiring more...

www.symrise.com

Contact:
Katja Derow, red roses communications GmbH, Phone: [phone]
770-10,
Email: [e-mail]

About BRAIN AG
BRAIN AG is an industrial "white" biotech company which discovers and
develops novel bioactive  natural compounds  and proprietary  enzymes
for its partners  and customers  in the  chemical and  pharmaceutical
industries, as well as  the food and  cosmetics industries. With  its
unique approach to  the discovery  and production  of new  biological
compounds and biocatalysts, the  company achieves creative  solutions
by harnessing nature's untapped biodiversity. Its success is built on
its proprietary BioArchive,  comprising millions  of genes,  proteins
and  metabolic  pathways  from  microbial  isolates  and   metagenome
libraries. Since its foundation in 1993, BRAIN has entered into  over
50 strategic collaborations  with nearly all  the relevant  companies
within the  chemical industry.  Currently,  BRAIN employs  72  highly
skilled people. BRAIN has entered into partnerships with BASF,  Ciba,
Clariant,  Evonik  Degussa,  Genencor,  Henkel,  Nutrinova,   Sandoz,
Schering,  Südzucker  and  Symrise,  to  name  but  a  few.  For  his
groundbreaking industrial biotechnology activities for a  sustainable
"biologisation of the chemical  industry" using nature`s toolbox  for
industrial  processes,  BRAIN  CEO  Dr.  Holger  Zinke  received  the
"Deutschen Umweltpreis 2008" of the "Deutsche Bundesstiftung Umwelt,"
(DBU).

www.brain-biotech.de

Contact:
Dr. Martin Langer, BRAIN AG, Corporate Development; Phone:
[phone],
Email: [e-mail]
Dr. Holger Zinke, BRAIN AG, CEO; Phone: [phone]
Email: [e-mail]


About AnalytiCon Discovery
The internationally operating AnalytiCon Discovery GmbH is the global
market leader in the field of natural product (NP) compound libraries
featuring fully  elucidated  structures.  With its  60  employees  at
Potsdam Biotech Campus,  it offers  services for every  phase of  the
supply chain  for  NP-based  drug  discovery  and  development.   The
company offers  the  full  range  of  services  for  the  accelerated
development of  NP-based lead  structures,  from procurement  of  raw
biomaterials to fermentation, isolation and high-throughput structure
elucidation all  the  way  to  NP-focused  medicinal  chemistry.  The
innovative technology  concept  employed  by AnalytiCon  has  led  to
top-class contracts with companies from the pharmaceutical, food  and
cosmetics industry in Europe, USA and Japan. Furthermore,  AnalytiCon
has established  the BIOS  concept  (Biology Oriented  Synthesis),  a
technology  for  developing   and  producing  focused   combinatorial
compound libraries  based on  rare NP  core structures  that  contain
bioactive structural elements  (Nat-DiverseTM). In  the process,  the
company has gained access to currently over 15% of all known  natural
products  worldwide  as  well  as  to  thousands  of  yet-unpublished
structures.

www.ac-discovery.com

Contact:
Dr. Lutz Müller-Kuhrt, AnalytiCon Discovery GmbH, Phone:
[phone],
Email: [e-mail]


 
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Symrise AG
Mühlenfeldstraße 1 Holzminden Germany

WKN: SYM999; ISIN: 
DE000SYM9999; Index: MDAX, TecDAX;
Listed: Amtlicher Markt in Frankfurter Wertpapierbörse, Freiverkehr 
in Bayerische Börse München, 
Freiverkehr in Hanseatische Wertpapierbörse zu Hamburg, Freiverkehr 
in Börse Berlin, 
Freiverkehr in Börse Düsseldorf, Freiverkehr in Börse Stuttgart, 
Prime Standard in Frankfurter Wertpapierbörse;