Directorate Change

Synexus Clinical Research PLC
06 June 2006


                 Synexus Clinical Research Plc ("the Company")
                               Directorate change

Synexus Clinical Research Plc is pleased to announce the appointment of Malcolm
Hughes (aged 52) as Non-Executive Director with immediate effect.

Malcolm is currently Chief Executive of Greenman Group plc ("Greenman"), a
private industrial company which supplies printer cartridges to European office
supplies distributors from its manufacturing base in Bulgaria. Prior to
Greenman, he was Chief Executive of Oasis Healthcare Plc for four years during
which Oasis grew from a small regional business to become the leading dental
practice owner/operator in the UK with turnover of over £70m. His previous
experience includes senior management roles at Chloride Group plc, Ladbroke
Group plc and Management Consulting Group plc.

Commenting on the appointment, Michael Fort, chief executive of Synexus said :

" I am delighted to welcome Malcolm to the Synexus board. He brings with him
considerable knowledge and expertise, not only within the healthcare industry
but also particular experience of business operations within the emerging
economies of Eastern Europe where Synexus has established a foothold and from
which we aim to expand rapidly. We look forward to benefiting from his
contribution to the development and implementation of our growth strategy."

Malcolm Hughes commented:

"I am delighted to be joining Synexus at a time when it is seeking to build on
its recent AIM flotation through expansion of its operations in the UK and
internationally. Its unique business model offers a strong proposition to global
pharmaceutical companies as they aim to develop more cost-effective methods of
trialling new drug treatments."

Additional Information

The following is a complete list of Mr Hughes' directorships as required under
Schedule 2(g) of the AIM Rules:

Current                          Previous in last 5 years
Greenman Group plc               Oasis Healthcare Plc
Greenman UK Limited              Oasis Dental Care Limited
Greenman Europe BV               The Dencare Management Group Limited
K2 Supplies Limited              Dencare Management Limited
Paprika Services Limited         Dencare Financial Services Limited
Betforum UK Limited              Dencare Developments Limited
                                 Dencare Implant Centres Limited
                                 Ora Dental Group Holdings Limited
                                 Ora Dental Group Limited
                                 Ora EBT Trustee Limited
                                 Inhoco 978 Limited
                                 Inhoco 979 Limited

There is no further information required to be disclosed under Schedule 2(g) of
the AIM Rules.

For further information:

Michael Fort, Chief Executive, Synexus Clinical Research PLC     01257 230 723

Zoe Biddick, Biddicks                                            020 7448 1000




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