Holding(s) in Company

Synexus Clinical Research PLC
06 April 2006


SYNEXUS CLINICAL RESEARCH PLC
06 APRIL 2006

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

SYNEXUS CLINICAL RESEARCH PLC

2. Name of shareholder having a major interest

CROWN PLACE VCT PLC

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

AS IN 2

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

SEE ADDITIONAL INFORMATION BELOW

5. Number of shares / amount of stock acquired

N/A

6. Percentage of issued class

N/A

7. Number of shares / amount of stock disposed

300,000

8. Percentage of issued class

1.32%

9. Class of security

ORDINARY GBP0.10 SHARES

10. Date of transaction

04 APRIL 2006

11. Date company informed

06 APRIL 2006

12. Total holding following this notification

2,422,259

13. Total percentage holding of issued class following this notification

10.63%

14. Any additional information

FIGURES BASED ON SHARES IN ISSUE OF 22,791,196.

NOTIFICATION ISSUED BY CLOSE VENTURE MANAGEMENT LIMITED.

15. Name of contact and telephone number for queries

16. Name and signature of authorised company official responsible for making
this notification

Date of notification

6 APRIL 2006




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