Holding(s) in Company

Synexus Clinical Research PLC
22 October 2007


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached (ii):


SYNEXUS CLINICAL RESEARCH PLC


2. Reason for the notification (please state Yes/No): ( )


An acquisition or disposal of voting rights: (YES)


An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached: ( )


An event changing the breakdown of voting rights: ( )


Other (please specify) : ( )


3. Full name of person(s) subject to the notification obligation (iii):


NEWTON INVESTMENT MANAGEMENT LIMITED


4. Full name of shareholder(s) (if different from 3.) (iv):


5. Date of the transaction (and date on which the threshold is crossed or
reached if different) (v):


18/10/07


6. Date on which issuer notified:


19/10/07


7. Threshold(s) that is/are crossed or reached:


DECREASE FROM 9.00% TO 8.83%


8. Notified details:


SALE OF 38,461 SHARES


A: Voting rights attached to shares

Class/type of shares if possible using    Situation previous to the Triggering
the ISIN CODE                                       transaction (vi)
                                        Number of      Number of voting Rights
                                        shares         (viii)

ORDINARY SHARES                         2,083,861      9.00%
GB00B0L2P93



Resulting situation after the triggering transaction (vii)

Class/type of shares if possible Number of  Number of voting     % of voting
using the ISIN CODE              shares     rights (ix)          rights

                                 Direct     Direct  Indirect     Direct Indirect
                                            (x)     (xi)

ORDINARY SHARES                  N/A        N/A      2,045,400   N/A      8.83%
GB00B0L2P93


B: Financial Instruments

Resulting situation after the triggering transaction (xii)

Type of     Expiration Exercise/       Number of voting rights that may  % of
financial   Date       Conversion      be acquired if the instrument is  voting
instrument  (xiii)     Period/ Date    exercised/ converted.             rights
                       (xiv)







Total (A+B)
Number of voting rights                      % of voting rights

2,045,400                                    8.83%


9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable (xv):

NEWTON INVESTMENT MANAGEMENT HOLDS THESE SHARES AS DISCRETIONARY INVESTMENT
MANAGERS


Proxy Voting:


10. Name of the proxy holder:


N/A


11. Number of voting rights proxy holder will cease to hold:


N/A


12. Date on which proxy holder will cease to hold voting rights:


N/A


13. Additional information:





14. Contact name:


ASIF S LALANI


15. Contact telephone number:

[phone]



                      This information is provided by RNS
            The company news service from the London Stock Exchange