Pre-Close Statement

Synexus Clinical Research PLC
10 April 2006





                         Synexus Clinical Research plc
                          ("Synexus" or "the Company")

                          Pre-Close Trading Statement


Synexus, the clinical trials services group, today announces the following
pre-close trading update ahead of its preliminary results for the year to 31
March 2006.

Further to the four months trading results reported in its AIM admission
document issued in November 2005, the Company is pleased to report that trading
has continued to be buoyant and that results for the year to 31 March 2006 are
therefore anticipated to be in line with management expectations.

Since its flotation, Synexus has vigorously pursued its stated strategy of
organic growth combined with strategic partnerships and acquisitions to expand
its business into emerging economies. To this end, Synexus has established the
first Site Management Organisation in India through a strategic alliance with
the Indian Clinical Research Institute. Furthermore, in January 2006, the
Company acquired the Polish clinical trials business Skandynawskie Centrum
Medyczne Sp. z.o.o. ("SCM"). This acquisition will allow Synexus to exploit the
growing opportunities for clinical trials and patient recruitment in Central and
Eastern European markets.

The Company continues to pursue a number of other opportunities to replicate its
business in new territories with particular emphasis on those within Central and
Eastern Europe and has a number of potential targets currently under review. The
Company is strengthening its management team at the senior operational level,
broadening its skills base and providing further capability to support its
growth, both in emerging clinical trial markets and in the UK.

Enquiries for our services remain strong and the forward order book covers
around 60% of the current market estimate of income for the year ending 31 March
2007.

Synexus expects to announce its preliminary results for the year to 31 March
2006 on 6 June 2006.


Press enquiries

Synexus Clinical Research plc                   Tel: [phone]
Michael Fort, Chief Executive

Biddicks - Financial Public Relations           Tel: [phone]
Zoe Biddick




                      This information is provided by RNS
            The company news service from the London Stock Exchange