Director/PDMR Shareholding

Fulcrum Pharma PLC
15 November 2006




                               FULCRUM PHARMA PLC

                                ('the Company')

                             Director Shareholding

The Company was informed on 15 November 2006 that Geoffrey Smith, Finance
Director, bought 500,000 ordinary shares in the Company at an average price of
3.69p per share.

As a result, Mr Smith now holds 1,403,333 ordinary shares, representing
approximately 1.09% per cent of the current issued share capital of the Company.




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