Holding(s) in Company

Fulcrum Pharma PLC
17 June 2002


             Fulcrum Pharma plc ('Fulcrum Pharma' or 'the Company')

                               Holding in Company


The Company has today been informed that World Life Sciences Limited has,
between 31 May 2002 and 13 June 2002, sold in aggregate 1,910,000 ordinary
shares in Fulcrum Pharma and now holds 1,750,000 ordinary shares representing
1.4% of the Company's issued share capital.


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