Transaction in Own Shares

For immediate release

23 September 2016

THE BIOTECH GROWTH TRUST PLC

(the "Company")

MARKET PURCHASE OF COMPANY’S OWN SHARES

Notification is given, pursuant to the authority granted at the Annual General Meeting of the Company held 12 July 2016 to make market purchases of the Company’s own shares up to an aggregate maximum of 8,754,920 that a market total of 55,216 Ordinary shares of 25p each in the capital of the Company were purchased on Friday, 23 September 2016 for cancellation by the Company at a price of 722.98 pence per share.

Following this transaction and in conformity with the provisions of the Transparency Directive, the Company hereby notifies the market that the total number of Ordinary shares that the Company has in issue, less the total number of Ordinary shares bought back for cancellation by the Company following such purchase, and therefore, the total number of voting rights in the Company is 57,218,215. The Company does not currently hold any Ordinary shares in treasury.

The figure of 57,218,215 may be used by shareholders as the denominator for the calculation by which they may determine if they are required to notify their interest in, or change to their interest in, the Company under the FCA’s Disclosure and Transparency Rules.

For and on behalf of

Frostrow Capital LLP

Company Secretary

For further information, please contact:

Mark Pope

Frostrow Capital LLP

Tel: [phone]