Director Dealing

For Immediate Release                                            31 July 2008

PROTEOME SCIENCES plc

("Proteome Sciences" or the "Company")

PRESS RELEASE

                           DIRECTORS' SHAREHOLDINGS                            

Proteome Sciences announces that on 31 July 2008 it granted a conditional award
of 1,882,500 Ordinary Shares of 1p each in the Company ("Ordinary Shares") to
C.D.J. Pearce, Chief Executive and of 1,170,000 Ordinary Shares of 1p each to
J.L. Malthouse, Finance Director, under its Long-Term Incentive Plan ("LTIP")
based on a closing mid-market price on 30 July 2008 of 20p per Ordinary Share.

In accordance with the rules of the LTIP, the Ordinary Shares awarded will vest
3 years after the date of grant subject to the Company achieving a target total
shareholder return (TSR) over a three-year performance period relative to the
AIM Healthcare Index at the start of that period. TSR is the aggregate of share
price growth and the value of dividend payments during the performance period.
No shares will be released unless the Company's TSR performance exceeds that of
the index, in which case 30% of the award will vest with full vesting only if
the Company's TSR performance exceeds that of the Index by 10%, with a pro-rata
award between 30% and 100% for each percentage point of out-performance up to
10%.

The Remuneration Committee of the Board of Directors believes that today's
award under the LTIP aligns the interests of shareholders with those of the
executive by making the award dependent on the success of management in
delivering superior returns to shareholders.

C.D.J. Pearce currently holds 6,538,075 shares in the Company, and has a
previous conditional award under the LTIP of up to 504,523 shares.

J.L. Malthouse currently holds 625,000 shares in the Company, and has a
previous conditional award under the LTIP of up to 470,352 shares.

                                     Ends                                      

Proteome Sciences plc

Christopher Pearce James Malthouse

Chief Executive Officer Finance Director

[e-mail] [e-mail]

Tel: [phone]

Nominated Adviser

Landsbanki Securities (UK) Limited

Shaun Dobson / Claes Spång Tel: [phone]