Holding(s) in Company

Proteome Sciences PLC ("the Company")                     

                              Notifiable Interest                              

                                                                               

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

An acquisition or disposal of voting rights

 

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

19th February 2008

6. Date on which issuer notified:

20th February 2008

7. Threshold(s) that is/are crossed or reached:

2

8. Notified details:

Below 3%

A: Voting rights attached to shares

Class/type   Situation previous to       Resulting situation after the         
of shares    Triggering transaction      triggering transaction                
                                                                               
if possible                              Notification required under DTR       
using ISIN                               transitional provision 7              
CODE                                                                           
             Number of   Number of       Number Number of       % of voting    
             Shares      Voting Rights   of     voting rights   rights         
                                         shares                                
                                                                               
                                                                               
                                                                               
                                         Direct Direct Indirect Direct Indirect
                                                                               
                                                                               
                                                                               
GB0003104196 4,016,641   4,016,641       Below  Below           Below          
                                         3%     3%              3%             
                                                                               

B: Financial Instruments

Resulting situation after the triggering transaction                           
                                                                               
                                                                               
                                                                               
Type of     Expiration Exercise/     Number of voting rights that may   % of   
financial   date       Conversion    be acquired if the instrument is   voting 
instrument             Period/ Date  exercised/ converted               rights 
                                                                               
                                                                               
                                                                               
                                                                               
                                                                               

Total (A+B)

Number of voting rights % of voting rights
                                          
                                          
                                          
3,910,513               Below 3%          
                                          
                                          
                                          

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

10. Name of the Proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

15. Contact email address:

[e-mail]