Holding(s) in Company

Proteome Sciences Plc ("the Company")                     

                              Notifiable Interest                              

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

Revised due to DTR rules - see section 13

3. Full name of person(s) subject to the notification obligation:

FMR Corp

4. Full name of shareholder(s) (if different from 3):

Fidelity Management & Research Company (FMRCO)

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

Revised due to DTR rules

6. Date on which issuer notified:

20 March 2007 (by fax & post)

7. Threshold(s) that is/are crossed or reached:

N/A

8. Notified details:

A: Voting rights attached to shares

Class/type of  Situation         Resulting situation after the triggering      
shares         previous to       transaction                                   
               Triggering                                                      
if possible    transaction       Notification required under DTR transitional  
using ISIN                       provision 7                                   
CODE                                                                           
               Number   Number   Number   Number of voting   % of voting rights
               of       of       of       rights                               
               Shares   Voting   shares                                        
                        Rights                                                 
                                 Direct   Direct  Indirect   Direct  Indirect  
                                                                               
Ordinary       780,842  780,842                   780,842            0.59%     
shares                                                                         
                                                                               
GB0003104196                                                                   

B: Financial Instruments

Resulting situation after the triggering transaction                         
                                                                             
Type of       Expiration     Exercise/      Number of voting  % of voting    
financial     date           Conversion     rights that may   rights         
instrument                   Period/ Date   be acquired if                   
                                            the instrument is                
                                            exercised/                       
                                            converted                        
                                                                             
NIL                                                                          

Total (A+B)

Number of voting rights                % of voting rights                    
                                                                             
780,842                                0.59%                                 

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

FMR Corp

FMRCO

10. Name of the Proxy holder:

FMR Corp

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

As discussed with the FSA, prior to the implementation of the EU Transparency
Directive, we aggregated the interests in shares of FMR Corp (FMR) and Fidelity
International Limited (FIL). According to the new DTR rules we are now
reporting the indirect holdings of FMR and FIL separately. A separate
notification is being submitted for FIL Corp. Please note these holdings are
correct as of close of business 16 March 2007.

14. Contact name:

Christopher Pearce or James Malthouse 01932 865065

Proteome Sciences PLC

Thilo Hoffmann 020 7426 9000

Teather & Greenwood Limited

15. Contact telephone number: