Blocklisting Interim Review

Shires Smaller Companies PLC
27 July 2007

                                   SCHEDULE 5

                        BLOCKLISTING SIX MONTHLY RETURN




1. Name of company      SHIRES SMALLER COMPANIES PLC



2. Name of scheme       BLOCK LISTING



3. Period of return:    From 22 October 2006 to 21 April 2007



4. Number and class of shares(s)
   (amount of stock/debt security)
   not issued under scheme                            826,773



5. Number of shares issued/allotted
   under scheme during period                         NIL



6. Balance under scheme not yet issued/allotted
   at end of period                                   826,773



7. Number and class of share(s)
   (amount of stock/debt securities)
   originally listed and the date of admission        900,000 - 20 October 2004


Please confirm total number of shares in issue at the end of the period
in order for us to update our records                 22,109,765

Contact for queries:          Address:

Name: GRAEME MCDONALD         SUTHERLAND HOUSE, 149 ST VINCENT STREET, GLASGOW

Telephone: [phone]






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